Influence of Massage and Occlusion on the Ex Vivo Skin Penetration of Rigid Liposomes and Invasomes

November 2013 in “ European journal of pharmaceutics and biopharmaceutics ”

Sindy Trauer, Heike Richter, Judith Kuntsche, R Büttemeyer, Manfred Liebsch, Michael Linscheid, Alfred Fahr, Monika Schäfer‐Korting, Jürgen Lademann, Alexa Patzelt

massage occlusion rigid liposomes flexible liposomes hair follicles ex vivo human skin follicular delivery liposomal formulation hydrophilic agents

Studysummary This study found that massaging the skin significantly increases follicular penetration of liposomes in an ex vivo setting, while occlusion only enhanced penetration for rigid liposomes.

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