Effects and Tolerability of Flutamide in Patients with Female Pattern Hair Loss

July 2013 in “ Surgery ”

Roberto Paradisi

flutamide female pattern hair loss FPHL androgens alopecia oral contraceptives

TLDR Flutamide effectively treats female pattern hair loss long-term with low doses being safe for the liver.

The study evaluated the long-term effects, safety, and tolerability of flutamide in 101 women with female pattern hair loss (FPHL) over a 4-year period. Participants received reducing doses of flutamide, with some also taking oral contraceptives. Results showed a significant decrease in alopecia scores after 12 months, with maximum effects observed after 2 years and maintained thereafter. Androgens were strongly suppressed during treatment. Initially, 4% of participants discontinued due to hepatic disorders, but no further hepatic issues were reported with lower doses. The study concluded that flutamide was an effective long-term treatment for FPHL, with low doses ensuring hepatic tolerability and high compliance.

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