A Randomized Trial of 5% Minoxidil Versus Combination of 5% Minoxidil and Oral Spironolactone in Treatment of Female Pattern Hair Loss

October 2019 in “ International Journal of Research in Dermatology ”

Nachiket Madhukarrao Palaskar, Nitin K. Chaudhari, Garima Laxminarayan Balpande, Swapna S Khatu

minoxidil spironolactone female pattern hair loss FPHL Sinclair grade Rogaine

TLDR Combining minoxidil and spironolactone is more effective for female hair loss, but minoxidil alone is sufficient after 6 months.

The study compared the effectiveness and safety of 5% topical minoxidil alone versus a combination of 5% topical minoxidil and oral spironolactone in treating female pattern hair loss (FPHL) in 100 patients. Results showed that after 6 months, the combination therapy group had a significantly lower mean Sinclair grade (2.56±0.50) compared to the minoxidil-only group (2.85±0.68, p=0.02). Additionally, the combination therapy group reported a significant improvement in quality of life at 12 months (26.93±2.25 vs 23.47±2.95, p<0.001). Both treatments were well-tolerated. The study concluded that the combination therapy had an additive effect, but its effectiveness plateaued at 6 months, recommending continuation with minoxidil alone thereafter.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 862 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 26 upvotes 4 months ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community For the ladies: Spironolactone for FPHL

in Female 13 upvotes 8 years ago

A 34 year old female with androgenic alopecia who has tried treatments such as Spironolactone, Desogen, Minoxidil and Finasteride in order to address her hair loss. It also details the experiences of other women taking Spironolactone for Female Pattern Hair Loss (FPHL).

community Spironolactone Update

in Female 10 upvotes 7 years ago

A woman's experience with Spironolactone as treatment for female pattern hair loss, including the effects of increasing dosage and her doctor's recommendation to try finasteride if no results are seen after 6 months. Other users have also shared their experiences with using finasteride for this condition.

community Low iron and hair loss connection

in Female 16 upvotes 9 months ago

A 39-year-old woman noticed hair thinning and found she has an iron deficiency, which may be linked to hair loss. Suggestions included seeing a dermatologist, using spironolactone, and minoxidil.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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