Depositing Alpha-Mangostin Nanoparticles to Sebaceous Gland Area for Acne Treatment

    November 2015 in “ Journal of pharmacological sciences ”
    Porntip Pan-In, Atthakorn Wongsomboon, Chayada Kokpol, Nuntaree Chaichanawongsaroj, Supason Wanichwecharungruang
    Studysummary This study found that applying α-mangostin-loaded nanoparticles significantly improved acne vulgaris in patients, with no notable skin irritation reported in human volunteers. Our plain-language summary of this paper — not a Tressless recommendation.
    The study investigated α-mangostin nanoparticles for acne treatment by targeting sebaceous glands via hair follicles. Cellulose-based nanoparticles with 50% α-mangostin loading were prepared, showing anti-P. acnes activity and sustained release in synthetic sebum. Minimal skin irritation was observed in a 2-week test with 20 volunteers. A 4-week split-face study with 10 acne patients showed significant improvement in acne severity and inflammatory lesions on the treated side. The results indicated effective entrapment and retention of nanoparticles at hair follicles, suggesting their potential for targeted acne treatment.
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