pH Stimulus-Responsive Hybrid Nanoparticles: A System Designed for Follicular Delivery of Brazilian Plant-Derived 5-Alpha-Reductase Enzyme Inhibitors

December 2023 in “ International Journal of Pharmaceutics ”

Renata Pinho Morais, Carolina Camargo de Oliveira, Izabel C. Riegel‐Vidotti, Cláudia Eliana Bruno Marino

pH-stimulus-responsive nanoparticles hybrid nanoparticles silica natural polymers chitosan sodium alginate Stryphnodendron adstringens extract 5-alpha-reductase enzyme inhibitors androgenetic alopecia hirsutism acne hair follicle Layer-by-Layer method zeta potential measurements 5-alpha-reductase inhibitors hair loss silica nanoparticles chitosan nanoparticles sodium alginate nanoparticles

Studysummary This study developed innovative silica/natural polysaccharide hybrid nanoparticles encapsulating plant-derived 5-alpha-reductase inhibitors, reporting effective controlled release at hair follicle pH and lower cytotoxicity, suggesting a promising delivery system for antiandrogenic treatments.

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