Thiolated and PEGylated Silica Nanoparticle Delivery to Hair Follicles

November 2020 in “ International journal of pharmaceutics ”

Jamila H. Al Mahrooqi, Vitaliy V. Khutoryanskiy, Adrian C. Williams

thiolated nanoparticles PEGylated nanoparticles silica nanoparticles hair follicles alopecia PEG keratin topical treatments

TLDR Using longer PEG chains helps nanoparticles penetrate hair follicles better, improving drug delivery for conditions like alopecia.

The study investigated the delivery of thiolated and PEGylated silica nanoparticles into hair follicles to enhance drug targeting for conditions like alopecia. It found that PEGylation, especially with higher molecular weight PEG (5000 Da), significantly improved nanoparticle penetration into hair follicles compared to thiolated nanoparticles, which tended to remain on the skin surface due to binding with keratin. This suggests that manipulating PEG chain length can enhance drug delivery to specific regions within hair follicles, potentially improving the efficacy of topical treatments.

View this study on centaur.reading.ac.uk →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery

27 citations , September 2018 in “Medicines”

Oleic acid nanovesicles improve minoxidil absorption in hair follicles for alopecia treatment.

Minoxidil-Encapsulated Poly(L-Lactide-Co-Glycolide) Nanoparticles with Hair Follicle Delivery Properties Prepared Using Solvent Evaporation and Sonication

research Minoxidil-Encapsulated Poly(L-Lactide-Co-Glycolide) Nanoparticles with Hair Follicle Delivery Properties Prepared Using Solvent Evaporation and Sonication

13 citations , February 2018 in “Bio-medical Materials and Engineering”

Minoxidil inside tiny particles can deliver more drug to hair follicles, potentially improving treatment for hair loss.

research Changing the Shape of Hair with Keratin Peptides

47 citations , January 2017 in “RSC Advances”

Keratin peptides can change hair shape gently without harsh chemicals.

research Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia

48 citations , January 2017 in “Skin Pharmacology and Physiology”

Finasteride-loaded nanoparticles may help treat alopecia.

Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

research Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

69 citations , December 2015 in “Journal of Controlled Release”

Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.

research Solid Lipid Nanoparticles Suspension Versus Commercial Solutions for Dermal Delivery of Minoxidil

26 citations , June 2011 in “International Journal of Pharmaceutics”

SLN suspensions work as well as commercial solutions for minoxidil delivery, but are non-corrosive, making them a promising alternative.

research Penetration and Storage of Particles in Human Skin: Perspectives and Safety Aspects

122 citations , April 2011 in “European Journal of Pharmaceutics and Biopharmaceutics”

Particles around 100 nm can penetrate and stay in hair follicles without passing through healthy skin, making them safe for use in topical products and useful for targeted drug delivery.

research Selective Follicular Targeting by Modification of the Particle Sizes

263 citations , February 2011 in “Journal of Controlled Release”

Medium-sized particles penetrate hair follicles better than smaller or larger ones, which could improve delivery of skin treatments.

research Follicular Transport Route: Research Progress and Future Perspectives

211 citations , February 2009 in “European journal of pharmaceutics and biopharmaceutics”

Hair follicles help absorb and store topical compounds, aiding targeted drug delivery.

research 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin

323 citations , April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

Only 40 nm nanoparticles can enter skin cells effectively for potential vaccine delivery.

research Differential Stripping: Determination of the Amount of Topically Applied Substances Penetrated into the Hair Follicles

162 citations , August 2005 in “The journal of investigative dermatology/Journal of investigative dermatology”

The new "differential stripping" method effectively measures how much substance gets into hair follicles.

research Development and Characterization of Minoxidil-Loaded Liposomal System for Delivery to Pilosebaceous Units

34 citations , March 2004 in “Journal of Liposome Research”

Minoxidil-loaded liposomes effectively deliver to hair follicles, potentially improving hair growth and treating alopecia.

research Variations of Hair Follicle Size and Distribution in Different Body Sites

405 citations , January 2004 in “Journal of Investigative Dermatology”

Hair follicle size and distribution vary significantly across different body sites.

Similar Research

5 / 116 results

research Trends in Nanotechnology for Practical Applications

9 citations , October 2018 in “Elsevier eBooks”

Nanotechnology is improving drug delivery and targeting, with promising applications in cancer treatment, gene therapy, and cosmetics, but challenges remain in ensuring precise delivery and safety.

Nanotechnology-Driven Delivery of Caffeine Using Ultradeformable Liposomes-Coated Hollow Mesoporous Silica Nanoparticles for Enhanced Follicular Delivery and Treatment of Androgenetic Alopecia

research Nanotechnology-Driven Delivery of Caffeine Using Ultradeformable Liposomes-Coated Hollow Mesoporous Silica Nanoparticles for Enhanced Follicular Delivery and Treatment of Androgenetic Alopecia

November 2024 in “International Journal of Molecular Sciences”

Nanoparticles may improve caffeine delivery for hair growth, offering a potential alternative to minoxidil for hair loss treatment.

research Bioactive Compound-Loaded Nanocarriers for Hair Growth Promotion: Current Status and Future Perspectives

October 2023 in “Plants”

Nanocarriers with plant extracts show promise for safe and effective hair growth treatment.

research Methodologies to Evaluate the Hair Follicle-Targeted Drug Delivery Provided by Nanoparticles

4 citations , July 2023 in “Pharmaceutics (Basel)”

Nanoparticle-based drug delivery to hair follicles is more effective when tested under conditions that match skin behavior.

research Development and Characterization of Thiolated Cyclodextrin-Based Nanoparticles for Topical Delivery of Minoxidil

December 2023 in “Pharmaceutics”

The new adhesive nanoparticles are effective for delivering Minoxidil to the scalp without skin irritation.