Thiolated and PEGylated Silica Nanoparticle Delivery to Hair Follicles

January 2021 in “ International journal of pharmaceutics ”

Jamila H. Al Mahrooqi, Vitaliy V. Khutoryanskiy, Adrian C. Williams

thiolated nanoparticles PEGylated nanoparticles silica nanoparticles hair follicles alopecia PEG keratin topical treatments

TLDR Using longer PEG chains helps nanoparticles penetrate hair follicles better, improving drug delivery for conditions like alopecia.

The study investigated the delivery of thiolated and PEGylated silica nanoparticles into hair follicles to enhance drug targeting for conditions like alopecia. It found that PEGylation, especially with higher molecular weight PEG (5000 Da), significantly improved nanoparticle penetration into hair follicles compared to thiolated nanoparticles, which tended to remain on the skin surface due to binding with keratin. This suggests that manipulating PEG chain length can enhance drug delivery to specific regions within hair follicles, potentially improving the efficacy of topical treatments.

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