Development and Characterization of Thiolated Cyclodextrin-Based Nanoparticles for Topical Delivery of Minoxidil

December 2023 in “ Pharmaceutics ”

Ammara Akhtar, Mohammad Waqas, Arshad Mahmood, Saira Tanvir, Talib Hussain, Mohsin Kazi, Munazza Ijaz, Mulazim Hussain Asim

thiolated cyclodextrin nanoparticles topical delivery Minoxidil thiolated β-cyclodextrin β-CDs hair loss scalp diseases Rogaine

TLDR The new adhesive nanoparticles are effective for delivering Minoxidil to the scalp without skin irritation.

The research paper presents the development of thiolated cyclodextrin-based nanoparticles for the topical delivery of Minoxidil, a drug used for treating hair loss. The nanoparticles were prepared with thiolated β-cyclodextrin (β-CDs) and Minoxidil. The thiolated β-CDs showed 1804.68 ± 25 μmol/g thiol groups and 902.34 ± 25 μmol/g disulfide bonds. The nanoparticles had sizes ranging from 231 ± 07 nm to 354 ± 13 nm and a zeta potential between −8.1 ± 02 mV and +16.0 ± 05 mV. The nanoparticles adhered well to human hair and improved drug retention. The study concluded that these nanoparticles could be a potential drug delivery system for topical scalp diseases.

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