Nanotechnology-Driven Delivery of Caffeine Using Ultradeformable Liposomes-Coated Hollow Mesoporous Silica Nanoparticles for Enhanced Follicular Delivery and Treatment of Androgenetic Alopecia

    Nattanida Thepphankulngarm, Suwisit Manmuan, Namon Hirun, Pakorn Kraisit
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    TLDR Nanoparticles may improve caffeine delivery for hair growth, offering a potential alternative to minoxidil for hair loss treatment.
    The study investigates the use of ultradeformable liposome-coated hollow mesoporous silica nanoparticles (ULp-Caf@HMSNs) to enhance caffeine delivery to hair follicles for treating androgenetic alopecia (AGA). These nanoparticles improve caffeine's skin penetration and controlled release, potentially increasing its efficacy in promoting hair growth. The ULp-Caf@HMSNs demonstrated good thermal stability, non-cytotoxicity, and reduced reactive oxygen species levels in DHT-damaged cells, suggesting they could be a promising alternative to minoxidil for hair loss treatment. However, challenges such as cost, scalability, and regulatory requirements need to be addressed for clinical application. The study emphasizes the need for further research to ensure consistency in nanoparticle production and to gather comprehensive safety and efficacy data for regulatory approval, with future efforts focusing on advancing toward human clinical trials.
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      community The theory that explains everything. Please help me make this big!

      in Research/Science  2448 upvotes 3 years ago
      The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

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