Cholecalciferol-Grafted Hollow Mesoporous Silica Nanoparticles for Targeted and Sustained Caffeine Delivery in Alopecia Therapy

    Nattanida Thepphankulngarm, Nutchalin Isariyavuth, Chomploy Renumas, Jarupha Meeyim, Suwisit Manmuan, Namon Hirun, Pakorn Kraisit
    TLDR Vitamin D3-coated nanoparticles effectively deliver caffeine for alopecia treatment with minimal side effects.
    This study introduces a novel method for treating alopecia using caffeine-loaded hollow mesoporous silica nanoparticles (HMSNs) grafted with cholecalciferol (vitamin D3). The cholecalciferol grafting enhances biocompatibility and targeting efficiency by interacting with vitamin D receptors in hair follicles, improving follicular penetration and prolonging caffeine release while minimizing side effects. The nanoparticles demonstrated effective drug delivery with reduced cytotoxicity, confirmed through various analyses and assays. The system's antioxidant and anti-inflammatory properties make it a promising solution for targeted alopecia therapy, with optimal particle sizes and mesoporous structures suitable for transdermal delivery.
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