Skin Targeting of an Optimized Caffeine Nanostructured Lipid Carrier With Improved Efficiency Against Chemotherapy-Induced Alopecia

November 2021 in “ Research Square (Research Square) ”

Amna M. A. Makky, Eman Sadddar, Doaa galaa, Abeer Khattab

caffeine nanostructured lipid carriers NLCs alopecia topical treatment stearic acid glyceryl monostearate particle size entrapment efficiency polydispersity index zeta potential confocal laser scanning microscopy permeation histological examination hair growth hair loss skin layers

TLDR The new caffeine cream works better for hair growth than existing products.

The study developed and optimized caffeine-loaded nanostructured lipid carriers (NLCs) for topical treatment of alopecia. The solubility of caffeine in stearic acid and glyceryl monostearate was 47.11 ± 3.048 and 32.67 ± 2.955 mg/g, respectively. The optimized formula showed a particle size of 358nm, entrapment efficiency of 72.55%, polydispersity index of 0.912, and zeta potential of -24.8. The release of the drug was 92.9 ± 4.9% after 4 hours. Confocal laser scanning microscopy showed improved permeation of caffeine-loaded NLCs to all skin layers. Histological examination confirmed the efficiency of the optimized caffeine NLCs formula in promoting hair growth compared to the market formula.

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