Nanostructured Lipid Carriers Composed of Argan Oil: A Potential Novel Vehicle for Caffeine Delivery to Stratum Corneum and Hair Follicles

January 2022 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”

Farideh Shiehzadeh, Elahe Mir, Safiye Raeesi, Sara Daneshmand, Javad Shahraki

nanostructured lipid carriers NLCs argan oil caffeine stratum corneum hair follicles topical treatment hair loss stearic acid surfactant span tween encapsulation efficiency nanoparticles

TLDR Argan oil-based nano carriers could potentially deliver caffeine to hair follicles to treat hair loss.

The study "Nanostructured lipid carriers (NLCs) composed of argan oil, the potential novel vehicle for caffeine delivery to stratum corneum and hair follicles" developed an optimal formulation of NLCs containing argan oil and caffeine as a potential topical treatment for hair loss. 26 batches were prepared and analyzed using various techniques. The optimal formulation consisted of 2% lipid, 2% surfactant, a stearic acid/argan oil ratio of 3.5, and a span/tween ratio of 1.25. The NLCs were spherical with a size of 256.2 nm, a polydispersity index of 0.225, and a zeta potential of -25.4. The caffeine encapsulation efficiency was 89%. In vivo studies showed that these nanoparticles can accumulate in the hair follicles over time, suggesting that this NLC formulation could be a potential method for delivering caffeine to hair follicles.

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