Skin Targeting of an Optimized Caffeine Nanostructured Lipid Carrier with Improved Efficiency Against Chemotherapy-Induced Alopecia

    July 2022 in “ International Journal of Applied Pharmaceutics ”
    AMNA MOHAMED MAKKY, EMAN SADDAR EL-LEITHY, DOAA GALAA HUSSEIN, ABEER KHATTAB
    Image of study
    TLDR The optimized caffeine formula improved hair growth and penetrated all skin layers.
    The study aimed to develop and optimize caffeine-loaded nanostructured lipid carriers (NLCs) for topical treatment of alopecia. The solubility of caffeine in stearic acid and glyceryl monostearate was found to be 47.11±3.048 and 32.67±2.955 mg/g, respectively. The optimized formula showed a particle size of 358 nm±1.45, entrapment efficiency of 72.55 %±0.12, polydispersity index of 0.912±0.030, and zeta potential of -24.8 mv±0.70. The release of the drug was 92.9±4.9 % after 2 hours. Confocal laser scanning microscopy showed improved permeation of caffeine-loaded NLCs to all skin layers. The histological examination confirmed the effectiveness of the optimized caffeine NLCs formula in promoting hair growth compared to the market formula.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 435 results

      community abusing caffeine boosts DHT levels!

      in Research/Science  1 upvotes 2 months ago
      Caffeine intake may increase DHT levels, but its impact on hair loss is minimal compared to genetic factors. Excessive caffeine can cause health issues, and its effects on hair loss are not directly applicable to humans based on rat studies.

      community Connection between caffeine and hair loss?

      in Product 3 months ago
      Caffeine might raise stress hormones, potentially worsening hair loss. Telogen effluvium is often misattributed to minor stressors rather than significant life events.

      community Caffeine + Dimethylglycine (DMG) Shampoo research

      in Research/Science  6 upvotes 4 months ago
      A user discusses the potential of caffeine and DMG in shampoo for treating hair loss, citing a pending patent and personal plans to test it. They find it more convenient than using minoxidil, tretinoin, and microneedling.

      community Caffeine affects on oral minoxidil

      in Chat  3 upvotes 7 months ago
      Caffeine may interfere with oral minoxidil because caffeine increases blood pressure while minoxidil lowers it. Users discuss potential interactions and effects on hair loss treatment.

      community Caffeine & Alopecia: What the Science Seems to Say

      in Research/Science  17 upvotes 1 year ago
      The conversation discusses the potential benefits of topical caffeine for Androgenetic Alopecia (APA) and female pattern hair loss. While some studies suggest positive results, there's no reliable scientific evidence to strongly recommend caffeine compounds for hair regrowth.

    Related Research

    1 / 1 results