Chitosan Nanoparticles for Topical Drug Delivery in Chemotherapy-Induced Alopecia: A Comparative Study of Five Repurposed Pharmacological Agents

    July 2025 in “ Pharmaceuticals
    Salma A. Fereig, John Youshia, Ghada M. El-Zaafarany, Mona G. Arafa, Mona M.A. Abdel-Mottaleb
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    TLDR Phenobarbital-loaded chitosan nanoparticles are promising for preventing hair loss from chemotherapy.
    This study explores the use of chitosan nanoparticles for topical delivery of five pharmacological agents to prevent chemotherapy-induced alopecia in C57BL/6 mice. Phenobarbital-loaded nanoparticles showed the most significant hair regrowth and quality improvements, followed by N-acetylcysteine and pioglitazone. Tacrolimus demonstrated moderate efficacy, while rifampicin was the least effective. The study concludes that phenobarbital-loaded chitosan nanoparticles are a promising approach for preventing and treating chemotherapy-induced alopecia, warranting further investigation for clinical applications.
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