Chitosan Nanoparticles for Topical Drug Delivery in Chemotherapy-Induced Alopecia: A Comparative Study of Five Repurposed Pharmacological Agents

July 2025 in “ Pharmaceuticals ”

Salma A. Fereig, John Youshia, Ghada M. El-Zaafarany, Mona G. Arafa, Mona M.A. Abdel-Mottaleb

chitosan nanoparticles topical drug delivery chemotherapy-induced alopecia phenobarbital N-acetylcysteine pioglitazone tacrolimus rifampicin chitosan hair regrowth hair loss alopecia

Studysummary In this study, chitosan nanoparticles loaded with phenobarbital were the most effective in promoting hair regrowth and quality in a mouse model of chemotherapy-induced alopecia, suggesting potential for preventing hair loss in cancer patients.

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