Treatment of Alopecia Totalis, Universalis, and Focalis with Vitamin D and Analogs: Three Case Reports and a Literature Review

The document presents three case studies of girls aged 1 and 5 with alopecia totalis, alopecia universalis, and alopecia focalis, who were treated with vitamin D and its analogs. The first two patients, who had not responded to other treatments, were given oral cholecalciferol for 6 months, followed by oral calcitriol and paricalcitol. The first patient regrew hair within 6 months and maintained results for 6 years. The second patient developed hypercalcemia-hypercalciuria on calcitriol, which was resolved by switching to paricalcitol, and observed hair regrowth at 6 months. The third patient's alopecia was completely resolved within 3 months on a daily high dose of cholecalciferol. The study concludes that vitamin D may have a therapeutic impact on alopecia, but further clinical trials are needed.