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    Did you mean 5-alpha-reductase inhibitor?
    Glossary 5-alpha-reductase inhibitor

    blocks enzyme converting testosterone to dihydrotestosterone (DHT)

    A 5-alpha-reductase inhibitor is a type of medication that blocks the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). By reducing DHT levels, these inhibitors can help treat conditions like male pattern baldness and benign prostatic hyperplasia (BPH).

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    Research 10 of 1000+

    1. pH STIMULUS-RESPONSIVE HYBRID NANOPARTICLES: A SYSTEM DESIGNED FOR FOLLICULAR DELIVERY OF BRAZILIAN PLANT-DERIVED 5-ALPHA-REDUCTASE ENZYME INHIBITORS International Journal of Pharmaceutics · 2023
    2. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition Psychoneuroendocrinology · 2018 · 37 citations
    3. Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat Journal of Pain · 2009
    4. Design of Liposome Formulations for CRISPR/Cas9 Enzyme Immobilization: Evaluation of 5-Alpha-Reductase Enzyme Knockout for Androgenic Disorders ACS Omega · 2023
    5. Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1 Bioorganic & medicinal chemistry · 2018 · 3 citations
    6. Novel 5α-Reductase Inhibitors:  Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005 · 18 citations
    7. Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach European journal of medicinal chemistry · 2012 · 17 citations
    8. The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-oxidoreductase Steroids · 1995 · 64 citations
    9. Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size Steroids · 2009 · 15 citations
    10. Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment F1000Research · 2021 · 1 citations
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    Community 10 of 1000+

    1. Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp Reddit · 19 May 2023
    2. I really hate how current hair loss treatment only rely on DHT blockers Reddit · 16 Nov 2023
    3. Fin/Dut and Metabolism Speeds… Reddit · 28 Aug 2024
    4. A warning to those using or thinking about using Dutasteride – Follow-up Reddit · 13 Mar 2021
    5. Has anyone here tried taking GLA supplements? Reddit · 16 Mar 2025
    6. Study shows further evidence that finasteride and dutasteride take 12-18 months or more to show significant results. Do NOT give up early Reddit · 25 Sept 2023
    7. How to BECOME a RESPONDER to Fin/Dut if you are not responding Reddit · 5 Aug 2023
    8. 5ar Type I in the frontal hair follicles - Dutasteride Reddit · 30 Apr 2024
    9. Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate. Reddit · 11 May 2023
    10. Which Saw Palmetto is good for blocking 5 alpha reductase, Serenoa repens or Chamaerops humilis? Reddit · 26 Jun 2020
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    Learn 6 of 24

    1. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    2. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    3. Neem Oil Oil from the neem tree, used in traditional remedies
    4. Saw Palmetto Palm-berry extract taken as a supplement
    5. Azelaic Acid Acid used in acne and rosacea creams
    6. Rosemary Herb whose oil is used in hair care
    All learn results →