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    Did you mean 5-alpha-reductase inhibitor?
    Glossary 5-alpha-reductase inhibitor

    blocks enzyme converting testosterone to dihydrotestosterone (DHT)

    A 5-alpha-reductase inhibitor is a type of medication that blocks the enzyme 5-alpha-reductase, which is responsible for converting testosterone into dihydrotestosterone (DHT). By reducing DHT levels, these inhibitors can help treat conditions like male pattern baldness and benign prostatic hyperplasia (BPH).

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    Research 30 of 1000+

    1. pH STIMULUS-RESPONSIVE HYBRID NANOPARTICLES: A SYSTEM DESIGNED FOR FOLLICULAR DELIVERY OF BRAZILIAN PLANT-DERIVED 5-ALPHA-REDUCTASE ENZYME INHIBITORS International Journal of Pharmaceutics · 2023
    2. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition Psychoneuroendocrinology · 2018 · 37 citations
    3. Finasteride, a 5alpha-reductase enzyme inhibitor, alone and synergism with a neurosteroid reduces responsiveness to nociceptive stimuli in male rat Journal of Pain · 2009
    4. Design of Liposome Formulations for CRISPR/Cas9 Enzyme Immobilization: Evaluation of 5-Alpha-Reductase Enzyme Knockout for Androgenic Disorders ACS Omega · 2023
    5. Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1 Bioorganic & medicinal chemistry · 2018 · 3 citations
    6. Novel 5α-Reductase Inhibitors:  Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005 · 18 citations
    7. Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach European journal of medicinal chemistry · 2012 · 17 citations
    8. The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-oxidoreductase Steroids · 1995 · 64 citations
    9. Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size Steroids · 2009 · 15 citations
    10. Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment F1000Research · 2021 · 1 citations
    11. Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors Current Drug Discovery Technologies · 2020 · 1 citations
    12. Pharmacophore and Atom Based 3D QSAR Studies on the Novel 5-Alpha-Reductase Inhibitors Indian Journal of Pharmaceutical Education · 2018 · 2 citations
    13. Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target Journal of Medicinal Chemistry · 2021 · 3 citations
    14. Finasteride: A slow-binding 5.alpha.-reductase inhibitor Biochemistry · 1993 · 70 citations
    15. Nipple Differentiation in Fetal Male Rats Treated with an Inhibitor of the Enzyme 5<i>α</i>-Reductase: Definition of a Selective Role for Dihydrotestosterone* Endocrinology · 1986 · 53 citations
    16. Theoretical Evaluation of Twenty-Cannabinoid Derivatives on Either Androgen Receptor or 5&alpha;-Reductase Enzyme Clinical cancer investigation journal · 2023 · 3 citations
    17. Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study Precision medicine and clinical omics · 2022 · 3 citations
    18. 5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice European Urology · 2013 · 7 citations
    19. 12-Methoxy Carnosic acid efficacy determinationand optimization through computational tools for 5alpha reductase enzyme and using finasteride as refrence molecule. Research Square (Research Square) · 2023
    20. Early embryonic exposure of freshwater gastropods to pharmaceutical 5-alpha-reductase inhibitors results in a surprising open-coiled “banana-shaped” shell Scientific reports · 2019 · 13 citations
    21. Extensive Challenges and Pending Advances in the Study of 5-Alpha-Reductase Isoenzymes. A Literature Review Latin American Journal of Development · 2024
    22. Synthesis and biological evaluation of 3-tetrazolo steroidal analogs: Novel class of 5α-reductase inhibitors Bioorganic & Medicinal Chemistry · 2015 · 17 citations
    23. Synthesis of mimics of steroid A ring as potential enzyme inhibitors Research Repository (Kingston University London) · 2002
    24. Predominant expression of 5 alpha-reductase type 1 in pubic skin from normal subjects and hirsute patients. 1996 · 11 citations
    25. Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995 · 12 citations
    26. 5 Alpha-Reductase Inhibitor Definitions · 2020
    27. In Search of Predictive Models for Inhibitors of 5-alpha Reductase 2 Based on the Integration of Bioactivity and Molecular Descriptors Data. IWBBIO · 2014
    28. Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat Journal of Pain · 2009 · 4 citations
    29. Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase Journal of Medicinal Chemistry · 1993 · 89 citations
    30. 5-alpha reductase inhibitors use in prostatic disease and beyond Translational Andrology and Urology · 2023