Double-Blind, Randomized, Placebo-Controlled Trial of a Cream Containing the Stryphnodendron Adstringens (Martius) Coville Bark Extract for Suppressing Terminal Hair Growth

The study evaluated the efficacy of a cream containing 6.0% Stryphnodendron adstringens bark extract for suppressing terminal hair growth in women with excessive hair. Conducted as a double-blind, randomized, placebo-controlled trial, the study found that 60.98% of subjects using the cream experienced significant benefits (P < 0.001), with the Ferriman-Gallwey score improving from 4 to 2, compared to 4 to 3 in the placebo group. The cream effectively reduced terminal hair growth and associated skin issues like hyperpigmentation, folliculitis, and acne, with no adverse events reported, suggesting it was a promising treatment for excessive terminal hair.