Microneedle-Mediated Hypoxic Extracellular Vesicle-Encapsulated Selenium Nanoparticles Delivery to Treat Androgenetic Alopecia

    March 2025 in “ Journal of Controlled Release ”
    Shuili Jing, Yonghao Liu, Ben Wang … Qingsong Ye
    Studysummary This study found that a biocomposite microneedle system, which includes selenium nanozyme and hypoxic extracellular vesicles, enhanced hair density and follicle diameter in androgenetic alopecia mice by fighting inflammation, promoting blood vessel growth, reducing reactive oxygen species, and counteracting androgen effects.
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    Research cited in this study 9

    1. A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch Bioactive Materials · 2022
    2. Machine Learning Guided Discovery of Superoxide Dismutase Nanozymes for Androgenetic Alopecia Nano Letters · 2022
    3. Conditioned Media-Integrated Microneedles for Hair Regeneration Through Perifollicular Angiogenesis Journal of Controlled Release · 2022
    4. A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy Advanced healthcare materials/Advanced Healthcare Materials · 2022
    5. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    6. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    7. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    8. Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth Theranostics · 2020
    9. Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development PLoS ONE · 2010