Gas-Propelled Anti-Hair Follicle Aging Microneedle Patch for the Treatment of Androgenetic Alopecia

    January 2025 in “ Journal of Controlled Release
    Yangyan Chen, Tao Ren, Wentao Wu, Beibei Yang, Airu Lu, Ke Pan, Jing Xu, Chao Lü, Guilan Quan, Chuanbin Wu, Xin Pan, Tingting Peng
    TLDR A new microneedle patch helps treat hair loss by improving drug delivery to hair follicles.
    The study introduces a novel gas-propelled microneedle patch loaded with ferrum-chelated puerarin/quercetin nanoparticles (PQFN) as an innovative treatment for androgenetic alopecia (AGA). This system enhances drug delivery to hair follicles, addressing oxidative stress and vascularization deficiencies that contribute to hair follicle aging. PQFN rejuvenates testosterone-induced senescence in dermal papilla cells by reducing reactive oxygen species, restoring mitochondrial function, and promoting angiogenesis. The gas-propelled microneedles improve drug penetration into deeper skin layers, leading to higher drug accumulation in hair follicles. Pharmacodynamic studies in an AGA mouse model demonstrated that PQFN-loaded microneedles significantly increased hair coverage by alleviating oxidative stress, promoting angiogenesis, and rejuvenating senescent cells, offering a promising anti-aging treatment strategy for AGA.
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