Synergistic therapeutic effect of ginsenoside Rg3 modified minoxidil transfersomes (MXD-Rg3@TFs) on androgenic alopecia in C57BL/6 mice

    Xiaxia Liu, Xiangming Kong, Xu Li, Yonghui Su, Sheng Xu, Xiaoya Pang, Ruifen Wang, Yu Ma, Qingping Tian, Liwen Han
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    TLDR Ginsenoside Rg3 combined with minoxidil was more effective in treating hair loss in mice.
    The study investigated the combined therapeutic effect of ginsenoside Rg3 and minoxidil on androgenetic alopecia (AGA) in C57BL/6 mice. Minoxidil is a first-line drug therapy for AGA, but its effectiveness can be limited by inflammation. Ginsenoside Rg3, a component of Ginseng, has anti-inflammatory properties and a steroidal structure similar to cholesterol, making it a potential substitute in the formulation of minoxidil transfersomes. The in vitro cell experiments showed that the combined use of minoxidil and Rg3 significantly reduced damage to hair follicle tissues caused by dihydrotestosterone (DHT), a hormone associated with hair loss. The researchers then prepared a novel minoxidil transfersome (MXD-Rg3@TFs) replacing cholesterol with Rg3, aiming to fully utilize the synergistic therapeutic effect of minoxidil and Rg3 on AGA.
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