Synergistic Therapeutic Effect of Ginsenoside Rg3 Modified Minoxidil Transfersomes on Androgenic Alopecia in C57BL/6 Mice

April 2024 in “ International Journal of Pharmaceutics ”

Xiaxia Liu, Xiangming Kong, Xu Li, Yonghui Su, Sheng Xu, Xiaoya Pang, Ruifen Wang, Yu Ma, Qingping Tian, Liwen Han

ginsenoside Rg3 minoxidil androgenetic alopecia C57BL/6 mice inflammation dihydrotestosterone hair follicle transfersomes cholesterol Ginseng Rogaine AGA DHT

TLDR Ginsenoside Rg3 combined with minoxidil was more effective in treating hair loss in mice.

The study investigated the combined therapeutic effect of ginsenoside Rg3 and minoxidil on androgenetic alopecia (AGA) in C57BL/6 mice. Minoxidil is a first-line drug therapy for AGA, but its effectiveness can be limited by inflammation. Ginsenoside Rg3, a component of Ginseng, has anti-inflammatory properties and a steroidal structure similar to cholesterol, making it a potential substitute in the formulation of minoxidil transfersomes. The in vitro cell experiments showed that the combined use of minoxidil and Rg3 significantly reduced damage to hair follicle tissues caused by dihydrotestosterone (DHT), a hormone associated with hair loss. The researchers then prepared a novel minoxidil transfersome (MXD-Rg3@TFs) replacing cholesterol with Rg3, aiming to fully utilize the synergistic therapeutic effect of minoxidil and Rg3 on AGA.

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