A Combination Therapy for Androgenic Alopecia Based on Quercetin and Zinc/Copper Dual-Doped Mesoporous Silica Nanocomposite Microneedle Patch

    January 2022 in “ Social Science Research Network ”
    Zhaowenbin Zhang, Wenbo Li, Di Chang, Zi-Qin Wei, Endian Wang, Jing Yu, Yuze Xu, Yumei Que, Yan-Xin Chen, Chen Fan, Yanling Zhou, Zhiguang Huan, Chen Yang, Feng Guo, Chen Yang
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    TLDR A new patch that releases quercetin, copper, and zinc ions under the skin can effectively treat hair loss by promoting hair follicle regeneration.
    The document presents a study on a combination therapy for androgenic alopecia (AGA) using a nanocomposite microneedle patch (ZCQ/MN) containing copper/zinc dual-doped mesoporous silica nanoparticles loaded with quercetin (ZCQ). The microneedle patch dissolves after skin penetration, releasing ZCQ nanoparticles that in turn release quercetin, copper, and zinc ions subcutaneously to promote hair follicle regeneration. The mechanism involves the regulation of AGA's main pathophysiological phenomena, including the inhibition of dihydrotestosterone and inflammation, promotion of angiogenesis, and activation of hair follicle stem cells. The study concludes that this systematic intervention targeting different pathophysiological links of AGA is an effective treatment strategy for hair loss, providing a theoretical basis for the development of biomaterial-based anti-hair loss therapy.
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