Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development

This study demonstrated that selenoproteins were crucial for proper skin and hair development, as well as keratinocyte function. Researchers generated mice lacking selenoproteins in keratin 14 expressing cells, which resulted in skin abnormalities, hyperplastic epidermis, aberrant hair follicle morphogenesis, and progressive alopecia. These mice also exhibited a runt phenotype and premature death. The findings highlighted the essential role of selenoproteins as antioxidants in the skin and their importance in keratinocyte growth and viability. The study provided genetic evidence linking severe selenoprotein deficiency to skin and hair abnormalities.