Selenoproteins Are Essential for Proper Keratinocyte Function and Skin Development

    August 2010 in “ PLoS ONE ”
    Aniruddha Sengupta, Ulrike Lichti, Bradley A. Carlson, Andrew Ryscavage, Vadim N. Gladyshev, Stuart H. Yuspa, Dolph L. Hatfield
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    Studysummary In this mouse study, severe selenoprotein deficiency in epidermal cells was linked to skin abnormalities, disrupted hair follicle development, and progressive alopecia, highlighting the role of selenoproteins in skin and hair health. Our plain-language summary of this paper — not a Tressless recommendation.
    This study demonstrated that selenoproteins were crucial for proper skin and hair development, as well as keratinocyte function. Researchers generated mice lacking selenoproteins in keratin 14 expressing cells, which resulted in skin abnormalities, hyperplastic epidermis, aberrant hair follicle morphogenesis, and progressive alopecia. These mice also exhibited a runt phenotype and premature death. The findings highlighted the essential role of selenoproteins as antioxidants in the skin and their importance in keratinocyte growth and viability. The study provided genetic evidence linking severe selenoprotein deficiency to skin and hair abnormalities.
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