Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product Demonstrating Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial
March 2026
in “
Preprints.org
”
Studysummary This study investigated the secretome of adipose mesenchymal stem cells and fibroblasts used in skin care products, finding 16 therapeutic pathways involving numerous signaling mechanisms, which may offer skin benefits through anti-inflammatory and regenerative effects.
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The study conducted a proteomic analysis of secretomes from adipose-derived stem cells (ADSCs) and fibroblasts used in the NeoGenesis Recovery skincare product, which showed efficacy in a double-blinded, vehicle-controlled clinical trial. The secretome contains a diverse array of proteins that contribute to reducing inflammation, promoting tissue regeneration, and maintaining skin health. Key proteins identified include those involved in collagen synthesis, wound healing, and anti-inflammatory processes. The study emphasizes the therapeutic potential of the complete secretome over isolated components, highlighting its role in enhancing skin health, reducing erythema and inflammation, and supporting wound healing. The findings suggest that protein damage, rather than DNA mutations, is a major cause of aging, and the secretome's proteins play a crucial role in maintaining skin health and function.
