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Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product Demonstrating Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial

research Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product That Has Demonstrated Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial

March 2026 in “Preprints.org”

This study investigated the secretome of adipose mesenchymal stem cells and fibroblasts used in skin care products, finding 16 therapeutic pathways involving numerous signaling mechanisms, which may offer skin benefits through anti-inflammatory and regenerative effects.

research Safety of skin care products during pregnancy.

10 citations , June 2011 in “PubMed”

This article suggests that most topical treatments for acne and unwanted hair growth are safe to use during pregnancy, except for hydroquinone and tretinoin, due to low systemic absorption.

research 856 Topical application of newly developed pseudoceramide improved both skin and hair barrier functions

April 2017 in “Journal of Investigative Dermatology”

Applying pseudoceramide improved skin and hair health.

research Advances in Nanotechnology-Based Topical Delivery Systems for Skincare Applications

January 2026 in “Pharmaceutics”

This review highlighted recent advances in nanocarrier-based topical delivery systems for skincare, emphasizing their potential to enhance ingredient stability, penetration, and targeted release while addressing specific pathophysiological skin concerns.

research Skin Care Properties of Grape Seed Polyphenols, a By-Product of the Winery Industry

October 2012 in “Humana Press eBooks”

This article discusses the historical and current uses of grape seeds in various industries but reports no new research findings.

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Community Join

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community Topical minoxidil and salicylic acid

4 upvotes 2 years ago

The user has been using finasteride for 6 months with decent results and recently added topical minoxidil. They are concerned that salicylic acid in their skincare products might reduce minoxidil's effectiveness.

community Eye bags from topical minoxidil — what actually worked for you?

6 upvotes 4 days ago

Minoxidil can cause under-eye bags due to fluid retention, and some users find relief by stopping its use or switching to oral forms. Collagen supplements, reducing sodium intake, and using skincare products like eye creams and sunscreen may help improve the appearance of eye bags.

community allergen of the year award list(2000-2023).most allergens are in every day shampoos and skin care.

in Research/Science 4 upvotes 3 years ago

The post discusses allergens in everyday shampoos and skincare products, listing yearly allergens from 2000 to 2023. It suggests that these chemicals might contribute to acne and hair loss.

community 2 % fucoidan significantly alleviated AGA symptoms, promoted hair growth, and increased hair density

21 upvotes 11 months ago

2% fucoidan alleviated AGA symptoms, promoted hair growth, and increased hair density in mice. Fucoidan is considered safe for humans as a supplement and topical skincare product, with potential therapeutic effects against AGA.

community I think microneedling before topical application of finasteride (or dut) is a path we should investigate (for those of us who don't care about systemic absorption). Here's why...

20 upvotes 1 year ago

Microneedling before applying topical finasteride or dutasteride may enhance their effectiveness by increasing local absorption in the scalp, despite concerns about systemic absorption. Users discuss combining this method with oral treatments and minoxidil, noting potential benefits and side effects.

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