Exploring the Dermatological Applications of Human Mesenchymal Stem Cell Secretome: A Comprehensive Review

    April 2025 in “ Stem Cell Research & Therapy ”
    Sona Zare, Alireza Jafarzadeh, Solmaz Zare, Amir Shamloo
    Studysummary This review suggests that MSC-derived conditioned media hold promise in dermatology, with studies indicating enhanced therapeutic effects when used alongside treatments like laser therapy and microneedling, leading to improved dermatological outcomes.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 10

    1. A Systematic Review of Case Series and Clinical Trials Investigating Regenerative Medicine for the Treatment of Vitiligo Journal of Cosmetic Dermatology · 2024
    2. Efficacy and Safety of Laser Therapy and Phototherapy in Cicatricial and Non-Cicatricial Alopecia: A Systematic Review Study Health Science Reports · 2024
    3. Regenerative Medicine in the Treatment of Specific Dermatologic Disorders: A Systematic Review of Randomized Controlled Clinical Trials Stem cell research & therapy · 2024
    4. Promotion of Hair Growth by a Conditioned Medium from Human Umbilical Cord Mesenchymal Stem Cells Cultivated in a 3D Scaffold of Gelatin Sponge European journal of medical research · 2024
    5. Umbilical Cord-Derived Mesenchymal Stem Cell Secretome Promotes Skin Regeneration and Rejuvenation: From Mechanism to Therapeutics Cell proliferation · 2023
    6. Exosomes for Hair Growth and Regeneration Journal of Bioscience and Bioengineering · 2023
    7. Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration Clinical, Cosmetic and Investigational Dermatology · 2023
    8. Conditioned Media-Integrated Microneedles for Hair Regeneration Through Perifollicular Angiogenesis Journal of Controlled Release · 2022
    9. Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review Frontiers in Cell and Developmental Biology · 2021
    10. Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation International Journal of Molecular Sciences · 2021