Proteomic Identification and Quantification of Secretory Proteins in Human Dermal Fibroblast-Conditioned Medium for Wound Repair and Hair Regeneration

    May 2023 in “ Clinical, Cosmetic and Investigational Dermatology ”
    Sang Bum Suh, Keun Jae Ahn, Eun Jeong Kim … Sung Bin Cho
    Studysummary In this study, human dermal fibroblast-conditioned medium was found to contain numerous proteins involved in wound repair and hair regeneration, with identified proteins forming interaction networks linked to key signaling pathways like epidermal growth factor receptor and transforming growth factor-β.
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    Research cited in this study 5

    1. The Potential Role of Fibroblast-Derived Multi-Peptide Factors in Activation of Growth Factors and Beta-Catenin in Hair Follicle Cells Journal of Cosmetic Dermatology · 2022
    2. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    3. Therapeutic Efficacy and Safety of a 1927-nm Fractionated Thulium Laser on Pattern Hair Loss: An Evaluator-Blinded, Split-Scalp Study Lasers in Medical Science · 2018
    4. Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth Dermatologic Surgery · 2012
    5. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007