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research Signaling pathways and targeted therapeutic strategies for polycystic ovary syndrome

October 2023 in “Frontiers in endocrinology”

This review investigates molecular mechanisms behind PCOS pathogenesis and discusses potential therapies, but reports no new clinical results.

research Molecular Mechanisms and Targeted Therapeutics in Androgenetic Alopecia: From Signaling Pathways to Regenerative Approaches

May 2026 in “Premier journal of science.”

This review examines androgenetic alopecia, detailing its causes and current treatments, but reports no new clinical results; the authors emphasize understanding its complexity for personalized therapy development.

Therapeutic Potential of Ishophloroglucin A from Ishige Okamurae in Androgenic Alopecia: Inhibition of 5α-Reductase Activity and Activation of the Wnt/β-Catenin Signaling Pathway in Human Dermal Papilla Cells

research Therapeutic potential of Ishophloroglucin a from Ishige okamurae in androgenic alopecia: inhibition of 5α-reductase activity and activation of the Wnt/β-catenin signaling pathway in human dermal papilla cells

January 2026 in “Applied Biological Chemistry”

This study found that Ishophloroglucin A from brown seaweed may treat androgenic alopecia by inhibiting 5α-reductase and promoting hair growth-related factors in human dermal papilla cells.

research Therapeutic Effects of Modified Changfa Zirong Powder on Androgenetic Alopecia through the Wnt/β-Catenin Signaling Pathway

November 2025 in “Phytomedicine”

Modified Changfa Zirong Powder improves hair growth in androgenetic alopecia.

Therapeutic Potential of Isoproterenol in Androgenetic Alopecia: Activation of Hair Follicle Stem Cells via the PI3K/AKT/β-Catenin Signaling Pathway

research Therapeutic potential of isoproterenol in androgenetic alopecia: activation of hair follicle stem cells via the PI3K/AKT/β-Catenin signaling pathway

June 2025 in “Stem Cell Research & Therapy”

In this study, researchers found that isoproterenol, an adrenergic β2 receptor agonist, promoted hair growth and hair follicle stem cell proliferation in models of androgenetic alopecia by modulating the PI3K/AKT/β-Catenin pathway, suggesting a potential new therapeutic strategy for hair loss.

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community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 1 year ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

community IGFBP‐rP1 is a potential therapeutic target in androgenic alopecia

in Research/Science 13 upvotes 1 year ago

IGFBP‐rP1 shows potential for treating androgenic alopecia by influencing hair cycle transitions. Increasing IGF-1 levels may have similar effects to Minoxidil and 5-AR inhibitors in reducing hair loss.

community Phase II for Technoderma Therepeutic's TDM-105795 set to begin in April tentatively

40 upvotes 3 years ago

Phase II for TDM-105795 for Androgenic Alopecia is set to begin in April 2023. The study aims to evaluate the efficacy and safety of TDM-105795 in male subjects.

community Keratin microspheres - breakthrough

14 upvotes 2 years ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community 2 % fucoidan significantly alleviated AGA symptoms, promoted hair growth, and increased hair density

21 upvotes 11 months ago

2% fucoidan alleviated AGA symptoms, promoted hair growth, and increased hair density in mice. Fucoidan is considered safe for humans as a supplement and topical skincare product, with potential therapeutic effects against AGA.

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