Solvent-Containing Closure Material Prevents Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin

January 2020 in “ Skin Pharmacology and Physiology ”

Anna Lena Klein, Markus Lubda, Paniz Akbarzadeh Taghavi, Jürgen Lademann, Ingeborg Beckers, Jörg von Hagen, Harald Kolmar, Alexa Patzelt

follicular penetration caffeine fluorescein sodium salt porcine ear skin solvent-containing nail varnish solvent-free varnish

Studysummary In this study using ex vivo porcine ear skin, researchers found that standard nail varnish applied gently creates effective follicular closures, preventing penetration of certain substances like fluorescein sodium salt and caffeine into hair follicles, whereas solvent-free varnish and rapid application techniques were less effective.

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