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research Solvent-Containing Closure Material Can Be Used to Prevent Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin

7 citations , January 2020 in “Skin Pharmacology and Physiology”

In this study using ex vivo porcine ear skin, researchers found that standard nail varnish applied gently creates effective follicular closures, preventing penetration of certain substances like fluorescein sodium salt and caffeine into hair follicles, whereas solvent-free varnish and rapid application techniques were less effective.

research Dermatological adverse events with taxane chemotherapy

141 citations , September 2016 in “European Journal of Dermatology”

This review examines dermatological side effects of taxane chemotherapy reported in past studies and highlights the necessity for identifying and managing these conditions to maintain cancer patients' quality of life; it presents no new clinical results.

Hair Follicles Contribute Significantly to Penetration Through Human Skin Only Shortly After Application as a Solvent Deposited Solid in Humans

research Hair follicles contribute significantly to penetration through human skin only at times soon after application as a solvent deposited solid in man

94 citations , May 2011 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology”

This study found that hair follicles contribute significantly to caffeine absorption shortly after topical application, with a faster absorption rate compared to the stratum corneum.

research Molecular characterization of xerosis cutis: A systematic review

33 citations , December 2021 in “PLoS ONE”

This review summarized multiple molecular markers studied for their association with dry skin, finding considerable variability and uncertainty about which markers best indicate xerosis cutis.

research Investigation of transfollicular caffeine penetration using microdialysis on ex vivo porcine ear skin

15 citations , October 2020 in “European journal of pharmaceutics and biopharmaceutics”

This study reported that combining microdialysis and selective follicular closure with varnish significantly reduces caffeine penetration through hair follicles in an ex vivo porcine ear skin model.

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community PG free Ru58841 solvent in the UK

2 upvotes 3 weeks ago

The conversation discusses finding a PG-free solvent for dissolving RU58841 in the UK, with glycerin suggested as a potential alternative. Water is also mentioned as a possible option.

community Alcohol-free minoxidil available in Europe

5 upvotes 9 months ago

Alcohol-free minoxidil options in Europe, particularly from a German pharmacy, are recommended for those with seborrheic dermatitis. Users suggest alternatives like Alopexy and Doppelherz foam, and emphasize avoiding propylene glycol and alcohol to reduce irritation.

community Making PG free solution at home

1 upvotes 2 years ago

A user wants to make a solution for RU58841 and finasteride powder using only glycerin and asks if ethanol is necessary. They are seeking advice on whether glycerin alone is sufficient.

community Does the PG-free version of RU58841 have lower absorption compared to the PG version?

6 upvotes 11 months ago

The conversation discusses the absorption and effectiveness of PG-free versus PG versions of RU58841, with some users believing PG improves efficacy while others see no difference. Concerns about RU58841's potential side effects on the endocrine system are also mentioned, with one user considering switching to pyrilutamide.

community Anyone in Australia found topical versions of minoxidil and finasteride that are free of Propylene Glycol?

in Treatment 1 upvotes 2 years ago

A user is seeking topical versions of minoxidil and finasteride in Australia that do not contain propylene glycol. They are looking for alternatives due to potential irritation from propylene glycol.

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