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    Did you mean JAK1/2 inhibitor?
    Glossary JAK1/2 inhibitor

    medication that blocks enzymes involved in immune signaling

    A JAK1/2 inhibitor is a type of medication that blocks the activity of Janus kinase 1 and 2 (JAK1 and JAK2), which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK1/2 inhibitors can help treat conditions like rheumatoid arthritis and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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    Research 30 of 774

    1. JAK inhibitors in dermatology: The promise of a new drug class Journal of the American Academy of Dermatology · 2017 · 355 citations
    2. Emerging Topical and Systemic JAK Inhibitors in Dermatology Frontiers in Immunology · 2019 · 277 citations
    3. Under Development JAK Inhibitors for Dermatologic Diseases Mediterranean Journal of Rheumatology · 2020 · 14 citations
    4. 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1) Journal of Investigative Dermatology · 2019 · 5 citations
    5. JAK-Inhibitors Beyond the Label: Emerging Applications in Dermatology Medicina · 2026
    6. Which is the ideal JAK inhibitor for alopecia areata – Baricitinib, tofacitinib, ritlecitinib or ifidancitinib - Revisiting the immunomechanisms of the JAK pathway Indian Dermatology Online Journal · 2023
    7. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015 · 184 citations
    8. JAK Inhibitors for Treatment of Alopecia Areata 2018 · 63 citations
    9. A Comprehensive Literature Review of JAK Inhibitors in Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021 · 40 citations
    10. Translational Positioning of Janus Kinase (JAK) Inhibitors in Alopecia Areata EBioMedicine · 2015 · 11 citations
    11. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    12. Alopecia Areata: Case report and review of pathophysiology and treatment with Jak inhibitors Journal of autoimmunity · 2022 · 6 citations
    13. Adverse events in patients treated with Jak‐inhibitors for alopecia areata: A systematic review 2023 · 2 citations
    14. Short-term Efficacy of Tofacitinib, a JAK Inhibitor, in IFIH1-related Aicardi-Goutières Syndrome European Journal of Medical Genetics · 2025
    15. Tofacitinib: The selected selective JAK inhibitor in paediatric dermatology International Journal of Dermatology Venereology and Leprosy Sciences · 2024
    16. A Review on the Use and Effectiveness of JAK Inhibitor in the Management of Lichen Planopilaris International Journal of Innovative Science and Research Technology (IJISRT) · 2024 · 1 citations
    17. 69 Risk-benefit appraisal of systemic JAK inhibitors for alopecia areata: a comprehensive meta-analysis assessing safety and adverse effects Journal of Investigative Dermatology · 2023
    18. 51840 Efficacy of the Oral JAK1/JAK2 Inhibitor Deuruxolitinib in Adult Patients with Moderate to Severe Alopecia Areata: Pooled Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 and THRIVE-AA2 Phase 3 Trials Journal of the American Academy of Dermatology · 2024 · 2 citations
    19. 41701 Efficacy of the Oral JAK1/JAK2 Inhibitor CTP-543 (Deuruxolitinib) in Adult Patients with Moderate to Severe Alopecia Areata: Results from the Multinational Double-Blind, Placebo-Controlled THRIVE-AA1 Phase 3 Trial Journal of the American Academy of Dermatology · 2023 · 2 citations
    20. JAK kinase pathway inhibitor drugs in patients with moderate-to-severe alopecia: a real-world experience e_Buah · 2024
    21. Comparative Efficacy and Safety of Janus Kinase Inhibitors Used in Alopecia Areata: A Systematic Review and Meta-analysis Acta dermato-venereologica · 2023 · 10 citations
    22. Alopecia Universalis in an Adolescent Successfully Treated with Upadacitinib—A Case Report and Review of the Literature on the Use of JAK Inhibitors in Pediatric Alopecia Areata Dermatology and therapy · 2023 · 9 citations
    23. Safety of Janus Kinase inhibitors in Patients with Alopecia Areata: A Systematic Review Clinical drug investigation · 2023 · 3 citations
    24. Janus kinase inhibitors for alopecia areata: A narrative review Indian journal of dermatology, venereology, and leprology · 2023 · 2 citations
    25. Janus Kinase Inhibitors in the Treatment of Alopecia Areata Prague Medical Report · 2023 · 2 citations
    26. Progressive alopecia areata during TNF-α inhibition with intralesional corticosteroid failure and subsequent improvement following JAK1 inhibition Journal of Dermatological Treatment · 2026 · 1 citations
    27. JAK1 gain-of-function variant causes alopecia areata, atopic dermatitis, and autoimmune thyroid disease Journal of Allergy and Clinical Immunology · 2025 · 1 citations
    28. Janus Kinase inhibitors in dermatology: a review Portuguese Journal of Dermatology and Venereology · 2023 · 1 citations
    29. The development of oral hairy leukoplakia during JAK inhibitor baricitinib therapy JAAD case reports · 2023
    30. Clinical evidence for JAK inhibition in alopecia areata: A comprehensive review 2026