Efficacy in Subgroups Related to Disease Characteristics in Patients with Alopecia Areata from BRAVE-AA1 and BRAVE-AA2

September 2023 in “ Journal of the American Academy of Dermatology ”

Tiffany Mayo, Susan Taylor, Taisuke Ito, Sergio Vañó Galván, Susan Ball, Na Lü, Chiara Chiasserinio, Yunfei Chen, Brittany G. Craiglow

baricitinib JAK1 inhibitor JAK2 inhibitor alopecia areata hair regrowth

TLDR Baricitinib significantly improves hair regrowth in severe alopecia areata.

The study titled "44096 Efficacy in Subgroups related to Disease Characteristics in Patients with Alopecia Areata from BRAVE-AA1 and BRAVE-AA2" evaluated the efficacy of baricitinib, an oral JAK1/JAK2 inhibitor, in treating adults with severe alopecia areata (AA). The results from the BRAVE-AA1 and BRAVE-AA2 trials demonstrated that baricitinib significantly improved hair regrowth in patients with AA, regardless of disease characteristics. The trials included a substantial number of participants, providing robust evidence for the effectiveness of baricitinib in this patient population. These findings support the use of baricitinib as a treatment option for severe AA in the US, Europe, and Japan.

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community What are the odds baricitinib will get a topical otc version for androgenic alopecia?

in Research/Science 1 year ago

Baricitinib, approved for alopecia areata, might be considered for treating receding hairlines. The discussion is about the possibility of an over-the-counter topical version for androgenic alopecia.

community Anyone heard of or have experience using baricitinib?

in Research/Science 1 upvotes 1 year ago

The conversation is about baricitinib, a medicine that can help with hair loss, and why it isn't more popular or widely discussed. No specific experiences with the treatment were shared.

community Olumiant active ingredient Baricitinib

in Research/Science 1 upvotes 1 year ago

The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

community Lilly to seek first approval of an autoimmune drug for hair loss

in Research/Science 19 upvotes 3 years ago

Eli Lilly's drug baricitinib showed effectiveness in treating alopecia areata, with higher doses resulting in significant hair regrowth compared to placebo. The treatment is not for male pattern baldness.

community Does a minoxidil tester exist? To test if whatever you get is actually minoxidil or some fake?

in Minoxidil 1 upvotes 7 months ago

The conversation discusses the uncertainty of the legitimacy of minoxidil products in the EU market and mentions baricitinib as an approved, but expensive alternative. A method to test for real minoxidil involves mixing it with bleach to see if it turns orange or brown.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

Related Research

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.