TLDR Baricitinib helps improve hair growth in severe alopecia, with better results in less severe cases and higher doses working faster.
The document is a post-hoc analysis of two phase 3 trials, BRAVE-AA1 and BRAVE-AA2, involving 855 patients, studying the efficacy of Baricitinib, an oral JAK1/JAK2 inhibitor, in treating severe alopecia areata (AA). The study found that both 2 mg and 4 mg doses of Baricitinib improved scalp hair growth up to week 52. Patients with a Severity of Alopecia Tool (SALT) score of 50-94 responded better than those with a score of 95-100. The 4 mg dose resulted in a faster and higher response rate than the 2 mg dose. However, patients with a baseline SALT score of 95-100 had a longer response time to treatment. The study concluded that the baseline severity of hair loss should be considered when setting expectations about treatment response.
148 citations,
March 2022 in “The New England Journal of Medicine” Baricitinib was effective in treating alopecia areata in two major trials.
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11 citations,
January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft” Alopecia areata is a chronic condition causing hair loss, with new treatments targeting the immune system showing promise.
13 citations,
February 2019 in “Journal of the American Academy of Dermatology” The document concludes that a new system using the SALT score should replace the current alopecia areata classification for better accuracy in assessing severity and prognosis.
36 citations,
November 2018 in “American Journal of Clinical Dermatology” Alopecia is linked to various health and mental conditions, impacts life quality, and needs medical attention beyond its cosmetic effects.
77 citations,
June 2017 in “Advances in Therapy” New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.
701 citations,
August 2014 in “Nature medicine” Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
April 2019 in “International journal of research in dermatology” A child with rough nails also had hair loss and allergies.
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