TLDR Baricitinib helps improve hair growth in severe alopecia, with better results in less severe cases and higher doses working faster.
The document is a post-hoc analysis of two phase 3 trials, BRAVE-AA1 and BRAVE-AA2, involving 855 patients, studying the efficacy of Baricitinib, an oral JAK1/JAK2 inhibitor, in treating severe alopecia areata (AA). The study found that both 2 mg and 4 mg doses of Baricitinib improved scalp hair growth up to week 52. Patients with a Severity of Alopecia Tool (SALT) score of 50-94 responded better than those with a score of 95-100. The 4 mg dose resulted in a faster and higher response rate than the 2 mg dose. However, patients with a baseline SALT score of 95-100 had a longer response time to treatment. The study concluded that the baseline severity of hair loss should be considered when setting expectations about treatment response.
Cited in this study
6 / 6 results
148 citations
,
May 2022 in “The New England Journal of Medicine” Baricitinib was effective in treating alopecia areata in two major trials.
11 citations
,
January 2022 in “Journal der Deutschen Dermatologischen Gesellschaft” Alopecia areata is a chronic condition causing hair loss, with new treatments targeting the immune system showing promise.
13 citations
,
February 2019 in “Journal of the American Academy of Dermatology” The document concludes that a new system using the SALT score should replace the current alopecia areata classification for better accuracy in assessing severity and prognosis.
36 citations
,
November 2018 in “American Journal of Clinical Dermatology” Alopecia is linked to various health and mental conditions, impacts life quality, and needs medical attention beyond its cosmetic effects.
77 citations
,
June 2017 in “Advances in Therapy” New treatments for Alopecia Areata, like JAK inhibitors, show promise for hair regrowth and are likely to change future treatment approaches.
701 citations
,
August 2014 in “Nature medicine” Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.
April 2019 in “International journal of research in dermatology” A child with rough nails also had hair loss and allergies.