Recent Insight on the Management of Lupus Erythematosus Alopecia

    March 2021 in “ Clinical, Cosmetic and Investigational Dermatology ”
    Karishma Desai, Mariya Miteva
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    TLDR Early treatment of Lupus Erythematosus Alopecia can prevent permanent hair loss, and various medications are effective.
    The 2021 document "Recent Insight on the Management of Lupus Erythematosus Alopecia" discussed various treatment strategies for Lupus Erythematosus Alopecia, a form of hair loss associated with the autoimmune disease Lupus Erythematosus. The paper highlighted the importance of early diagnosis and treatment to prevent permanent hair loss. Topical therapies such as corticosteroids and calcineurin inhibitors, and systemic therapies like antimalarials, immunosuppressants, and biologics were found to be effective. For non-scarring alopecia in Systemic Lupus Erythematosus (SLE), controlling SLE activity led to hair regrowth, while in Chronic Cutaneous Lupus Erythematosus (CLE), the goal was to prevent progression of hair loss. First-line therapies for CLE included topical corticosteroids and oral antimalarials. Other treatments such as methotrexate, dapsone, mycophenolate mofetil, thalidomide, lenalidomide, and Janus Kinase inhibitors showed promise but were associated with severe side effects. The document concluded that more research was needed to develop more effective treatments.
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      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      community 2 years of fin, 1.5 years of minoxidil, calling it quits. Thank you.

      in Shaved/buzzed  567 upvotes 2 years ago
      This user has been struggling with hair loss for the past two years and attempted to treat it using finasteride and minoxidil. Despite their efforts, they have not seen any improvement in their condition, so they have decided to shave or buzz their head instead. Others gave advice on other treatments that could be tried if desired.

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      in Finasteride/Dutasteride  21 upvotes 2 years ago
      The conversation suggests that people should consult a dermatologist to understand their type of hair loss before starting treatments like finasteride or dutasteride, especially if they have autoimmune issues or low DHT. Some participants believe in starting treatment like finasteride immediately if hair loss is due to DHT, while others recommend ruling out other causes and considering minoxidil first, especially for younger individuals.

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