Successful Hair Regrowth with Multimodal Treatment of Early Cicatricial Alopecia in Discoid Lupus Erythematosus

    January 2009 in “ Acta Dermato Venereologica ”
    Trevor D. Hamilton, Nina Otberg, Wu Wy, Michal Martinka, J Shapiro
    TLDR Early and aggressive treatment can significantly regrow hair in discoid lupus erythematosus.
    In this 2009 case report, a 37-year-old man with early cicatricial alopecia due to discoid lupus erythematosus (DLE) experienced significant hair regrowth following an aggressive multimodal treatment regimen. The treatment included oral prednisone, hydroxychloroquine, topical clobetasol, topical tacrolimus, and intralesional triamcinolone acetonide injections. After 4 months, approximately 80% hair regrowth was observed, and no further progression of scalp lesions was detected. This case highlighted the importance of early and aggressive treatment in preventing irreversible hair loss in DLE.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 8 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Losing Hair on Dutasteride? You might have LPP

      in Research/Science  99 upvotes 1 month ago
      Men with hair loss might have lichen planopilaris (LPP), which can mimic androgenetic alopecia, leading to misdiagnosis and ineffective treatment with finasteride or dutasteride. Proper diagnosis, including biopsies, is crucial to distinguish between androgenetic alopecia and conditions like LPP.

      community Totally confused by doctors opinions, would appreciate some clarity

      in Treatment  1 upvotes 4 months ago
      The user is experiencing hair loss and confusion over conflicting medical advice, with treatments including minoxidil, finasteride, and topical corticosteroids. They are unsure about the necessity of a biopsy and the timing of using minoxidil, while also considering the impact of potential androgenetic alopecia and telogen effluvium.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  56 upvotes 1 month ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

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