TLDR Interferon gamma alone can't cause alopecia areata in C3H/HeJ mice.
The study tested whether exogenous interferon gamma could induce alopecia areata in C3H/HeJ mice, a model for this autoimmune disease. Despite inducing anagen by wax stripping and injecting recombinant murine interferon gamma, the frequency and onset of alopecia did not change. This suggested that interferon gamma alone was not sufficient to initiate alopecia areata in these mice.
Cited in this study
4 / 4 results
20 citations
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December 2005 in “Journal of Investigative Dermatology Symposium Proceedings” IFN-γ and IL-2 are important for T cell activation in hair loss in mice.
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December 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Understanding normal hair follicle development helps analyze abnormalities in mutant mice.
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January 2002 in “Dermatology” A woman's hair loss during treatment with specific hepatitis C drugs grew back after stopping the medication.
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November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” Skin grafts on mice can cause an immune response leading to hair loss, useful for studying human hair loss conditions.
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February 2007 in “Journal of experimental animal science” Interferon gamma alone can't cause alopecia areata in C3H/HeJ mice.
