Birth, Life, and Death of the MAGE3 Hypothesis of Alopecia Areata Pathobiology

    August 2013 in “ Journal of Dermatological Science ”
    Taisuke Ito, Marta Bertolini, Akihiro Funakoshi, Natsuho Ito, Tatsuya Takayama, Tamás Bı́ró, Ralf Paus, Y. Tokura
    TLDR The MAGE3 hypothesis for alopecia areata did not lead to a significant breakthrough.
    The document detailed the research journey of investigating the MAGE3 hypothesis in the context of alopecia areata (AA), an autoimmune disease. Despite initial hopes, the hypothesis did not lead to a clinically significant breakthrough. The study highlighted the challenges and educational value of scientific research, even when it does not result in the anticipated success.
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