Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

    June 2022 in “ Molecules
    Mohammed Faiz Arshad, Aftab Alam, Abdullah Alshammari, Mohammed Bader Alhazza, Ibrahim Mohammed Alzimam, Md Anish Alam, Gulam Mustafa, Mohd Imran, Abdulelah Alotaibi, Abdullah A. Alotaibi, Suresh Kumar, Syed Mohammed Basheeruddin Asdaq, Mohd Imran, Pran Kishore Deb, Katharigatta N. Venugopala, Shahamah Jomah
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    TLDR Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.
    The document reviews the role of thiazole, a chemical structure with sulfur and nitrogen, in drug development. Thiazole-based compounds have shown potential in various medical applications. They have demonstrated significant anticonvulsant properties, with several compounds showing high activity. Thiazole derivatives have also shown promise as potential anticancer agents, with molecules 9 and 10 showing the most promise. They have also demonstrated antibacterial properties, with compounds 37a, 37b, and 37c showing effective action against all tested bacterial strains. Thiazole-based compounds have also shown excellent anti-tubercular action, with compound 53 showing the highest activity. These compounds have also shown potential as anti-inflammatory, antimalarial, and antiviral agents. They have also been tested for their potential as anti-Alzheimer's drugs, with several compounds demonstrating promising results. Thiazole-based compounds have also shown potential as anti-diabetic agents and A1-receptor antagonists. The document concludes by emphasizing the potential of thiazole-derived compounds in the development of future drugs.
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