Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

    December 2018 in “ Cell stem cell ”
    Pallavi Gupta, Ievgenia Pastushenko, Adam Skibinski … Charlotte Kuperwasser
    Studysummary This study suggests that phenotypic plasticity, including processes like dedifferentiation and transdifferentiation, plays a crucial role in cancer initiation, progression, and therapy resistance, broadening our understanding of cancer dynamics and potential treatment strategies.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 6

    1. YAP And TAZ Are Essential For Basal And Squamous Cell Carcinoma Initiation EMBO Reports · 2018
    2. Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition Cell stem cell · 2016
    3. Dedifferentiation of Committed Epithelial Cells Into Stem Cells In Vivo Nature · 2013
    4. Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair Cell · 2012
    5. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    6. Distinct Stem Cells Contribute to Mammary Gland Development and Maintenance Nature · 2011