Molecular Monitoring of Short- and Long-Term Transcriptional Effects of Hair Growth Stimulating Agents

    December 2024 in “ PLoS ONE
    Sabrina K. Henne, Lara M. Hochfeld, Wilhelm Bartmann, Thomas Welss, Markus M. Nöthen, Stefanie Heilmann‐Heimbach
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    TLDR Hair growth serums A and C can affect hair growth genes and pathways, suggesting potential for personalized hair loss treatments.
    The study on 91 male participants examined the molecular effects of three hair growth serums on male-pattern hair loss by analyzing RNA and microRNA expression in hair follicles. Over short (4 days) and long (6 weeks) treatment periods, 52 genes and 17 pathways were differentially expressed, with 23% of genes showing significant changes after just 4 days. Notably, serums A and C showed significant effects, with genes like NDUFB7 and GPX4 being differentially expressed, suggesting impacts on mitochondrial function and hair morphogenesis. The study underscores the potential of molecular monitoring and genetic profiling to provide early insights into treatment efficacy and personalize hair loss therapies, despite being exploratory with a limited sample size.
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