Characterization of the Epidermal-Dermal Junction in hiPSC-Derived Skin Organoids

    May 2022 in “ Stem cell reports ”
    Veronika Ramovs, Hans Janssen, Ignacia Fuentes … Karine Raymond
    Studysummary This study reported that human induced pluripotent stem cell-derived skin organoids, used to model epidermolysis bullosa, have an epidermal-dermal junction largely lacking type VII collagen, which is important for skin structure.
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    Research cited in this study 5

    1. Generation And Characterization Of Hair-Bearing Skin Organoids From Human Pluripotent Stem Cells Nature Protocols · 2022
    2. Skin Organoids: A New Human Model for Developmental and Translational Research Experimental Dermatology · 2021
    3. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    4. Lineage Identity and Location Within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin Journal of Investigative Dermatology · 2018
    5. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin: The Absence of Type VII Collagen Is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000