Therapeutic Potential of Patient iPSC-Derived Melanocytes in Autologous Transplantation

    April 2019 in “ Cell reports ”
    Liping Liu, Yumei Li, Ningning Guo … Yun‐Wen Zheng
    Studysummary This study found that human iPSC-derived melanocytes from vitiligo patients successfully integrated into mouse hair follicles and epidermis, demonstrating potential for personalized therapy for depigmentation.
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    Research cited in this study 12

    1. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    2. Repigmentation Through Melanocyte Regeneration in Vitiligo Dermatologic clinics · 2017
    3. Direct Conversion of Mouse and Human Fibroblasts to Functional Melanocytes by Defined Factors Nature Communications · 2014
    4. Skin Melanocytes: Biology and Development Postepy Dermatologii I Alergologii · 2013
    5. Melanocyte Stem Cells: A Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation Pigment Cell & Melanoma Research · 2011
    6. Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells Cell stem cell · 2011
    7. The Cell Biology of Human Hair Follicle Pigmentation Pigment cell & melanoma research · 2010
    8. Human Dermal Stem Cells Differentiate Into Functional Epidermal Melanocytes Journal of Cell Science · 2010
    9. Isolation and Short-Term Culture of Primary Keratinocytes, Hair Follicle Populations, and Dermal Cells from Newborn Mice and Keratinocytes from Adult Mice for In Vitro Analysis and Grafting to Immunodeficient Mice Nature Protocols · 2008
    10. Expression Patterns of MITF During Human Cutaneous Embryogenesis: Evidence for Bulge Epithelial Expression and Persistence of Dermal Melanoblasts Journal of cutaneous pathology · 2008
    11. Dermatosurgical Techniques for Repigmentation of Vitiligo International Journal of Dermatology · 2006
    12. Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2005