Therapeutic Potential of Patient iPSC-Derived Melanocytes in Autologous Transplantation

    April 2019 in “ Cell reports ”
    Liping Liu, Yumei Li, Ningning Guo, Shu Li, Xiaolong Ma, Yixuan Zhang, Yimeng Gao, Jianling Huang, Dongxu Zheng, Lu-Yuan Wang, Hui Xu, Lijian Hui, Yun‐Wen Zheng
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    TLDR Patient-derived melanocytes can potentially treat vitiligo by restoring skin pigmentation.
    The study demonstrated that human iPSC-derived melanocytes (hiMels) from vitiligo patients, generated using a three-dimensional system, exhibited characteristics similar to human epidermal melanocytes and were involved in vitiligo-associated signaling pathways. In vivo experiments showed that these hiMels localized in the mouse hair bulb and epidermis, producing melanin for up to 7 weeks post-transplantation. Additionally, hiMelanocyte stem cells integrated into the bulge-subbulge regions. These findings highlighted the potential of hiMels for long-term reconstitution of pigmented hair follicles and integration into normal skin regions, suggesting a promising personalized cellular therapy for depigmentation.
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