TLDR Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.
The document "Melanocytes in regenerative medicine applications and disease modeling" explores the critical roles of melanocytes in pigmentation, photoprotection, and immune response, and their involvement in disorders like melanoma and albinism. It highlights advancements in stem cell technologies, CRISPR/Cas9, and tissue engineering for disease modeling and therapy development. The review emphasizes the importance of understanding melanocyte biology, including melanosome maturation and melanin transfer mechanisms, to improve treatments for pigmentary disorders and melanoma. It also discusses innovative tools like 3D spheroids and extracellular vesicles for drug testing and modeling, advocating for advanced in vitro models to better mimic in vivo conditions.
67 citations
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November 2019 in “Nature Communications” Oncogenic melanocyte stem cells can develop into melanoma similar to human cases.
31 citations
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April 2019 in “Cell reports” Patient-derived melanocytes can potentially treat vitiligo by restoring skin pigmentation.
33 citations
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December 2015 in “International Journal of Molecular Sciences” Melanocyte stem cells are crucial for skin pigmentation and have potential in disease modeling and regenerative medicine.
3 citations
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November 2023 in “Frontiers in cell and developmental biology” Melanocytes are important for skin and hair color and protect the skin from UV damage.
1 citations
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September 2013 in “Elsevier eBooks” Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.
13 citations
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April 2022 in “Frontiers in oncology” Melanoma development can be linked to the breakdown of skin's melanin-producing units.
January 2011 in “Springer eBooks” Eating a balanced diet with the right vitamins and minerals is important for healthy hair, but too many supplements can be harmful.
75 citations
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August 2018 in “Biochemical pharmacology” Targeting the skin's endocannabinoid system could help treat skin disorders.
