Melanocytes in Regenerative Medicine Applications and Disease Modeling

    April 2024 in “ Journal of translational medicine ”
    Kelly Coutant, Brice Magne, Karel Ferland, Aurélie Fuentes-Rodriguez, Olivier Chancy, Andrew D. Mitchell, Lucie Germain, Solange Landreville
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    TLDR Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.
    The document "Melanocytes in regenerative medicine applications and disease modeling" explores the critical roles of melanocytes in pigmentation, photoprotection, and immune response, and their involvement in disorders like melanoma and albinism. It highlights advancements in stem cell technologies, CRISPR/Cas9, and tissue engineering for disease modeling and therapy development. The review emphasizes the importance of understanding melanocyte biology, including melanosome maturation and melanin transfer mechanisms, to improve treatments for pigmentary disorders and melanoma. It also discusses innovative tools like 3D spheroids and extracellular vesicles for drug testing and modeling, advocating for advanced in vitro models to better mimic in vivo conditions.
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