Melanocytes in Regenerative Medicine Applications and Disease Modeling

April 2024 in “ Journal of translational medicine ”

Kelly Coutant, Brice Magne, Karel Ferland, Aurélie Fuentes-Rodriguez, Olivier Chancy, Andrew D. Mitchell, Lucie Germain, Solange Landreville

melanocytes hair follicles pigmentation photoprotection immunity stem cell technology tissue engineering extracellular vesicles

TLDR Melanocytes are important for normal body functions and have potential uses in regenerative medicine and disease treatment.

The document "Melanocytes in regenerative medicine applications and disease modeling" explores the critical roles of melanocytes in pigmentation, photoprotection, and immune response, and their involvement in disorders like melanoma and albinism. It highlights advancements in stem cell technologies, CRISPR/Cas9, and tissue engineering for disease modeling and therapy development. The review emphasizes the importance of understanding melanocyte biology, including melanosome maturation and melanin transfer mechanisms, to improve treatments for pigmentary disorders and melanoma. It also discusses innovative tools like 3D spheroids and extracellular vesicles for drug testing and modeling, advocating for advanced in vitro models to better mimic in vivo conditions.

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Research cited in this study

2 / 2 results

research Therapeutic Potential of Patient iPSC-Derived Melanocytes in Autologous Transplantation

31 citations, April 2019 in “Cell reports”

Patient-derived melanocytes can potentially treat vitiligo by restoring skin pigmentation.

research Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications

33 citations, December 2015 in “International Journal of Molecular Sciences”

Melanocyte stem cells are crucial for skin pigmentation and have potential in disease modeling and regenerative medicine.

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research Aging and Anti-Aging in Hair and Hair Loss

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research Loss of Epidermal Melanin Unit Integrity in Human Skin During Melanoma Genesis

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research The Endocannabinoid System of the Skin: A Potential Approach for the Treatment of Skin Disorders

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Melanocytes in Regenerative Medicine Applications and Disease Modeling

Research cited in this study

research Therapeutic Potential of Patient iPSC-Derived Melanocytes in Autologous Transplantation

research Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications

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