Potential Application of PBM in Hair Follicle Organoid Culture for the Treatment of Androgenic Alopecia

The document explores the potential use of photobiomodulation (PBM), a form of light therapy, in hair follicle organoid culture for treating androgenic alopecia, a hereditary hair loss condition. Current treatments like minoxidil, finasteride, and herbal supplements are not universally effective and can have side effects. The paper proposes a novel regenerative treatment using hair follicle organoids, 3D cell aggregates that mimic the structure and function of hair follicles. PBM has been shown to improve cell viability, proliferation, migration, differentiation, and gene expression in dermal papilla cells and hair follicle stem cells, making it a potential adjunct to hair follicle organoid culture. The document also discusses other treatments like Low-Level Laser Therapy, Platelet-Rich Plasma, microneedling, and non-surgical options, but highlights the need for regenerative treatments with permanent effects. The document suggests that PBM could assist in overcoming current challenges in large-scale production of hair follicle organoids for clinical applications.