Androgenetic Alopecia: Update on Etiology

June 2021 in “ Dermatological reviews ”

Rachita Dhurat, Sanober Burzin Daruwalla

androgenetic alopecia AGA genetics androgens dihydrotestosterone DHT miniaturizing hair follicles polygenic inheritance microinflammation oxidative stress medications hair transplantation hair follicle miniaturization

TLDR AGA, a common hair loss, is caused by genetics, hormones, age, and environmental factors.

This document provides an update on the causes of androgenetic alopecia (AGA), the most common form of hair loss in both men and women. AGA is influenced by genetics, androgens, and age, with dihydrotestosterone (DHT) playing a key role in miniaturizing hair follicles. The condition is caused by interactions among several genes and environmental factors, and a polygenic mode of inheritance is more likely than previously thought. Other factors that contribute to AGA include microinflammation, oxidative stress, and environmental factors. The document also covers treatment options such as medications and hair transplantation.

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No cure for female pattern hair loss, but various effective treatments exist.

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Oxidative stress damages hair and contributes to aging, and managing it can help maintain hair health.

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ESR2 gene variations may be linked to female pattern hair loss.

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6 / 6 results

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