Effects of Photobiomodulation at Various Irradiances on Normal and Dihydrotestosterone-Treated Human Hair Dermal Papilla Cells In Vitro

    July 2023 in “ Journal of Biophotonics ”
    Miao Sun, Hui Jiang, Shangfei Lin … Muqing Liu
    Studysummary This study found that red light at an irradiance of 8 mW/cm² was most effective in promoting growth and modulating signaling pathways in dermal papilla cells treated with dihydrotestosterone, suggesting the need for personalized photobiomodulation treatment approaches for androgenetic alopecia.
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    Research cited in this study 28

    1. Mechanistic Synergy of Hair Growth Promotion by the Avicennia Marina Extract and Its Active Constituent Avicequinone C in Dermal Papilla Cells Isolated From Androgenic Alopecia Patients PLOS ONE · 2023
    2. Photobiomodulation Promotes Hair Regeneration in Injured Skin by Enhancing Migration and Exosome Secretion of Dermal Papilla Cells Wound repair and regeneration · 2021
    3. Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth Frontiers in Cell and Developmental Biology · 2021
    4. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    5. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    6. Culture and Differentiation of Human Hair Follicle Dermal Papilla Cells in a Soft 3D Self-Assembling Peptide Scaffold Biomolecules · 2020
    7. Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods Skin Pharmacology and Physiology · 2020
    8. Low-Level Laser Therapy for the Treatment of Androgenetic Alopecia in Thai Men and Women: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Trial Lasers in Medical Science · 2018
    9. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    10. Generation of Trichogenic Adipose-Derived Stem Cells by Expression of Three Factors Journal of Dermatological Science · 2018
    11. Comparison of the Effects of 665 nm Low-Level Diode Laser Hat Versus a Combination of 665 nm and 808 nm Low-Level Diode Laser Scanner on Hair Growth in Androgenic Alopecia Journal of Cosmetic and Laser Therapy · 2017
    12. Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process Clinical, Cosmetic and Investigational Dermatology · 2017
    13. Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways Annals of Dermatology · 2017
    14. Drug Discovery for Alopecia: Gone Today, Hair Tomorrow Expert Opinion on Drug Discovery · 2015
    15. Visible Red Light Enhances Physiological Anagen Entry In Vivo And Has Direct And Indirect Stimulatory Effects In Vitro Lasers in surgery and medicine · 2014
    16. Minoxidil May Suppress Androgen Receptor-Related Functions Oncotarget · 2014
    17. Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-Controlled, Double-Blind Study American Journal of Clinical Dermatology · 2014
    18. The Growth of Human Scalp Hair Mediated by Visible Red Light Laser and LED Sources in Males Lasers in Surgery and Medicine · 2013
    19. Low-Level Laser Therapy for Treatment of Hair Loss Lasers in Surgery and Medicine · 2013
    20. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    21. Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia British Journal of Dermatology · 2012
    22. Androgen Receptor Transactivity Is Potentiated by TGF-β1 Through Smad3 but Checked by Its Coactivator Hic-5/ARA55 in Balding Dermal Papilla Cells Journal of Dermatological Science · 2011
    23. L-Ascorbic Acid 2-Phosphate Represses Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Balding Dermal Papilla Cells Experimental Dermatology · 2010
    24. Preventable Effect of L-Threonate, an Ascorbate Metabolite, on Androgen-Driven Balding via Repression of Dihydrotestosterone-Induced Dickkopf-1 Expression in Human Hair Dermal Papilla Cells BMB Reports · 2010
    25. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    26. Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells Skin Pharmacology and Physiology · 2006
    27. Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    28. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002

    Related research 7

    1. Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes Journal of St. Marianna University · 2022
    2. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    3. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    4. Hair Follicle Reformation Induced by Dermal Papilla Cells from Human Scalp Skin Archives of Dermatological Research · 2006
    5. Study on Hair Follicle Formation Induced by Dermal Papilla Cells Chinese Journal of Reparative and Reconstructive Surgery · 2003
    6. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001
    7. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998