Effects of Photobiomodulation at Various Irradiances on Normal and Dihydrotestosterone-Treated Human Hair Dermal Papilla Cells In Vitro

July 2023 in “ Journal of Biophotonics ”

Miao Sun, Hui Jiang, Shangfei Lin, Haokuan Qin, Xiaolei Ding, Yongxian Lai, Shangfeng Liu, Muqing Liu

photobiomodulation red light dihydrotestosterone DHT dermal papilla cells DPCs androgenetic alopecia AGA Wnt signaling pathway FGF signaling pathway TGF signaling pathway Shh pathway red light therapy hair loss androgenic alopecia

TLDR Red light at 8 mW/cm2 most effectively promotes hair cell growth and affects key growth pathways, especially in cells treated with a hair loss-related hormone.

The study "Effects of photobiomodulation at various irradiances on normal and dihydrotestosterone‐treated human hair dermal papilla cells in vitro" investigated the impact of red light at different irradiances on normal and dihydrotestosterone (DHT)-treated dermal papilla cells (DPCs), which are related to androgenetic alopecia (AGA), a common type of hair loss. The results suggested that red light at 8 mW/cm2 was most effective in promoting DPCs growth. Additionally, a range of irradiances from 2 to 64 mW/cm2 modulated key signaling pathways, including Wnt, FGF, and TGF, in both normal and DHT-treated DPCs. Interestingly, 8 mW/cm2 had a greater impact on these pathways in DHT-treated DPCs and altered the Shh pathway, indicating that the effect of photobiomodulation varies with the cellular environment. The study emphasizes the need for personalized photobiomodulation treatment approaches.

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