Effects of Photobiomodulation at Various Irradiances on Normal and Dihydrotestosterone-Treated Human Hair Dermal Papilla Cells In Vitro

In this study, researchers found that crude extracts from Avicennia marina and its component avicequinone C inhibit mechanisms contributing to androgenic alopecia in vitro, including 5α-reductase activity and DHT-AR interactions, potentially promoting hair growth and delaying the catagen phase in human dermal papilla cells.

This study found that photobiomodulation enhanced hair regeneration in injured dermis of mice, likely through increased migration and exosome secretion of dermal papilla cells via the Akt/GSK-3β/β-catenin pathway.

This study found that 3D-cultured dermal papilla cells more accurately mimic in vivo conditions compared to 2D cultures, enhancing our understanding of molecular mechanisms in androgen-induced alopecia.

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

This review discusses the role of Wnt/β-catenin signaling in hair follicle regeneration and highlights recent progress in developing hair loss treatments targeting this pathway, but reports no new clinical results.

The study suggests that a 3D culture system using the RAD16-I peptide scaffold can help restore the original phenotype of hair follicle dermal papilla cells and support their osteogenic and adipogenic differentiation.

This review discusses the biology and signaling mechanisms of dermal papilla cells in hair follicle growth and reports no new clinical results; the authors emphasize the importance of optimizing culture conditions for hair restoration.

In a 24-week randomized trial, this study found that the RAMACAP laser helmet significantly increased hair density and diameter in androgenetic alopecia patients compared to a sham device, although limitations included a small sample size and potential issues with the control used.

This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.

This study observed that adipose-derived stem cells modified with trichogenic factors have similar properties to dermal papilla cells and show enhanced hair regeneration potential compared to unmodified adipose-derived stem cells.

This study reported that a new laser scanner using 655 nm red and 808 nm infrared lasers significantly improved hair density in patients with androgenic alopecia compared to both a laser hat and no treatment, without observable adverse effects.

In this study, a topical formulation with compounds from the monoterpenoid family significantly improved hair growth indicators like anagen:telogen ratio, hair fall, and visual hair density in men and women with pattern hair loss.

This study suggests that LED light may promote the proliferation of human dermal papilla cells through the activation of specific signaling pathways.

This review discusses current knowledge on the biological mechanisms of different types of alopecia but reports no new clinical findings; the authors highlight future research directions, especially regarding epidermal stem cells and immune pathways.

This study found that red light accelerated the transition from the resting to growth phase in hair follicles faster than green and blue light in mice, suggesting it may stimulate hair growth.

This study found that minoxidil suppressed androgen receptor functions and stability, suggesting its potential use in treating diseases related to the androgen-AR pathway.

This study found that low-level laser treatment with the HairMax Lasercomb significantly increased terminal hair density in both men and women with pattern hair loss, with no serious adverse events reported.

This study found that low level laser therapy at 655 nm significantly increased hair counts in males with androgenetic alopecia.

This review discusses the potential mechanisms and evidence supporting low-level laser therapy for stimulating hair growth in men and women, while noting its safety and effectiveness but needing further study on specific parameters.

This study found that valproic acid promoted hair re-growth in C3H mice by activating the Wnt/β-catenin pathway, suggesting its potential as a treatment for alopecia.

This study found that androgens inhibit hair follicle stem cell differentiation by disrupting the Wnt signalling pathway in dermal papilla cells, but Wnt activation can restore differentiation.

TGF-β1 increases androgen receptor activity in hair loss, but Hic-5/ARA55 can counter this effect.

This study found that L-ascorbic acid 2-phosphate could reduce DHT-induced DKK-1 expression in balding scalp cells, suggesting potential for treating androgen-driven hair loss.

In this study, L-threonate was found to inhibit DHT-induced DKK-1 expression in cultured dermal papilla cells, suggesting it could help prevent androgen-driven balding.

The researchers reported that DHT-inducible DKK-1 may play a significant role in DHT-driven balding by inhibiting hair follicle cell growth and promoting apoptosis in androgenetic alopecia.

This study found that testosterone and 5α-dihydrotestosterone induced apoptosis in dermal papilla cells from nonbalding scalp regions, suggesting a high androgen stimulus can trigger cell death related to androgenetic alopecia.

TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.

This study found that finasteride improves scalp hair growth in men with male pattern hair loss by reducing scalp dihydrotestosterone levels, but it did not benefit postmenopausal women with female pattern hair loss.