Platelets as Regenerative Cells, Hundreds of Opportunities in Sight

August 2024 in “ OBM Transplantation ”

Elga Jhoanna Vargas, Ana Luisa Muñoz, Lina Andrea Gómez

platelet-rich plasma growth factors cytokines regenerative medicine angiogenic immunomodulatory cell differentiation tissue regeneration PRP

Studysummary This article reviews the use of platelet concentrates in regenerative medicine and highlights the need for standardized protocols and more specific clinical studies, without reporting new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

Platelets, known for their role in hemostasis and thrombosis, also contain growth factors and secrete cytokines, making them valuable in regenerative medicine. Their properties, including chemotactic, angiogenic, immunomodulatory, and cell differentiation capabilities, have been harnessed to promote tissue regeneration in bones, tendons, ligaments, and wounds. The efficacy and safety of platelet-rich plasma (PRP) have been demonstrated, but standardized protocols and clinical studies are necessary to optimize outcomes. The variability in platelet count, growth factors, and application methods can affect results, highlighting the need for personalized approaches.

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research Adverse Events Related to Platelet-Rich Plasma Therapy and Future Issues to Be Resolved

44 citations , June 2024 in “Regenerative Therapy”

This review discusses adverse events potentially linked to platelet-rich plasma therapy, highlighting the need for more high-quality evidence to understand its safety profile and associated risks.

research Efficacy of Autologous Platelet-Rich Plasma Therapy Versus Topical Minoxidil in Men With Moderate Androgenetic Alopecia: A Randomized Open-Label Trial

February 2023 in “Journal of Dermatological Treatment”

In this study, both platelet-rich plasma and minoxidil increased hair counts and density in moderate androgenetic alopecia in men, but patient satisfaction was higher with minoxidil, which also had fewer side effects.

research Effect of Platelet Counts and Activator in Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia, Split-Head Comparison: A Randomised, Double-Blind Study

January 2023 in “Indian Journal of Dermatology, Venereology and Leprology”

In this study, activated platelet-rich plasma improved hair density and thickness in patients with androgenetic alopecia, with higher platelet counts enhancing these effects over time.

research Treatment of Androgenetic Alopecia Using PRP to Target Dysregulated Mechanisms and Pathways

5 citations , March 2022 in “Frontiers in Medicine”

This review analyzed 17 recent clinical trials on platelet-rich plasma for androgenetic alopecia but reports no new clinical results; the authors seek a consensus on optimal PRP use.

research Platelet Rich Plasma and Its Use in Hair Regrowth: A Review

18 citations , March 2022 in “Drug design, development and therapy”

This review examines the definition, classification, mechanism, clinical efficacy for hair regrowth, and potential adverse effects of platelet rich plasma, but does not present new experimental results.

research Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management

290 citations , August 2021 in “Clinical Reviews in Allergy & Immunology”

JAK inhibitors show promise for treating alopecia areata, but more research is needed.

research Platelet-Rich Plasma and Regenerative Dentistry

87 citations , March 2020 in “Australian Dental Journal”

This review discusses different preparation and application methods of platelet-rich plasma in dental regenerative medicine and reports no new results, highlighting its potential and associated controversies.

research Growth Factor and Growth Factor Receptor Localization in the Hair Follicle Bulge and Associated Tissue in Human Fetus

94 citations , March 1996 in “Journal of Investigative Dermatology”