Platelet-Rich Plasma in Regenerative Medicine: Biological Mechanisms, Preparation Methods, Clinical Applications, and Current Challenges
January 2025
in “
International Research Journal of Innovations in Engineering and Technology
”
Studysummary This review discusses the biological mechanisms, preparation techniques, and clinical applications of platelet-rich plasma therapy, highlighting its variable outcomes and potential improvements for efficacy and standardization; it reports no new clinical results.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Platelet-rich plasma (PRP) is a promising technique in regenerative medicine due to its ability to promote tissue healing, new blood vessel formation, and extracellular matrix regeneration through concentrated growth factors like PDGF, TGF-β, VEGF, EGF, and IGF-1. However, the effectiveness of PRP therapy varies significantly depending on preparation methods, activation techniques, and patient-specific factors such as age and existing conditions. This review highlights the need for standardization and improved efficacy in PRP applications across various fields, including orthopedics, dermatology, dentistry, and wound healing. Emerging techniques like exosome-enriched PRP and therapies combining biomaterials or stem cells may address current challenges and enhance clinical outcomes.
