Platelet-Rich Plasma And Platelet Fibrin: Standardized Preparation Protocols, Mechanisms Of Activation, Storage Stability, And Regulatory Frameworks

    December 2025 in “ Eastern Ukrainian Medical Journal ”
    Mykhailo V. Khyzhnyak, I. G. Vasilyeva, Oleksandr Potapov … Yuri Gafiychuk
    Studysummary This study reviews current methods for making and using platelet-rich plasma and fibrin, emphasizing the variability in clinical outcomes due to differences in preparation protocols, and calls for standardized guidelines and large-scale studies for better effectiveness in regenerative medicine.
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    Research cited in this study 6

    1. The Evolution of Three Generations of Platelet Concentrates Products: A Leap from Classical Formulations to the Era of Extracellular Vesicles Frontiers in Bioengineering and Biotechnology · 2025
    2. Re-Evaluating Platelet-Rich Plasma Dosing Strategies in Sports Medicine: The Role of the '10 Billion Platelet Dose' in Optimizing Therapeutic Outcomes—A Narrative Review Journal of Clinical Medicine · 2025
    3. Long-Term Stability of Frozen Platelet-Rich Plasma Under −80°C Storage Condition Regenerative Therapy · 2024
    4. A Comprehensive Review on Platelet-Rich Plasma Activation: A Key Player in Accelerating Skin Wound Healing Curēus · 2023
    5. Immunomorphological Features of Women's Skin with Androgenetic Alopecia in the Treatment of Plasma Enriched with Platelets in Combination with Topical Minoxidil 2% Lotion Journal of V. N. Karazin Kharkiv National University: Series Medicine · 2021
    6. Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020 International Journal of Molecular Sciences · 2020