Platelet-Rich Plasma And Platelet Fibrin: Standardized Preparation Protocols, Mechanisms Of Activation, Storage Stability, And Regulatory Frameworks

    December 2025 in “ Eastern Ukrainian Medical Journal ”
    Mykhailo V. Khyzhnyak, I. G. Vasilyeva, Oleksandr Potapov, Oleksandr Tsyndrenko, Yuri Gafiychuk
    TLDR Standardized protocols are crucial for effective use of platelet-rich plasma and fibrin in tissue regeneration.
    This document reviews the preparation, biological properties, and clinical application of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), emphasizing the need for standardized protocols. It highlights the role of platelet-derived biomaterials in promoting tissue regeneration and discusses factors affecting their efficacy, such as donor parameters and centrifugation techniques. The review also addresses regulatory aspects, particularly in Ukraine, and stresses the importance of methodological harmonization and large-scale clinical studies to improve comparability of outcomes and implement GMP standards in production.
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