Platelet-Rich Plasma And Platelet Fibrin: Standardized Preparation Protocols, Mechanisms Of Activation, Storage Stability, And Regulatory Frameworks

December 2025 in “ Eastern Ukrainian Medical Journal ”

Mykhailo V. Khyzhnyak, I. G. Vasilyeva, Oleksandr Potapov, Oleksandr Tsyndrenko, Yuri Gafiychuk

platelet-rich plasma platelet-rich fibrin tissue regeneration platelet-derived biomaterials centrifugation techniques GMP standards PRP PRF

Studysummary This study reviews current methods for making and using platelet-rich plasma and fibrin, emphasizing the variability in clinical outcomes due to differences in preparation protocols, and calls for standardized guidelines and large-scale studies for better effectiveness in regenerative medicine.

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research The Evolution of Three Generations of Platelet Concentrates Products: A Leap from Classical Formulations to the Era of Extracellular Vesicles

6 citations , August 2025 in “Frontiers in Bioengineering and Biotechnology”

This review discusses the evolution of platelet concentrates in regenerative medicine, highlighting a proposed function-driven classification that distinguishes three generations of PCs by biological activity rather than development order, with third-generation exosome-based therapies showing superior therapeutic efficacy over earlier formulations.

research Re-Evaluating Platelet-Rich Plasma Dosing Strategies in Sports Medicine: The Role of the '10 Billion Platelet Dose' in Optimizing Therapeutic Outcomes—A Narrative Review

15 citations , April 2025 in “Journal of Clinical Medicine”

This review reports that platelet-rich plasma may be more effective for musculoskeletal conditions when prepared with high platelet doses and low leukocyte content, but further trials are needed to confirm optimal formulations.

research Long-Term Stability of Frozen Platelet-Rich Plasma Under −80°C Storage Condition

5 citations , June 2024 in “Regenerative Therapy”

This study found that freezing PRP at -80 °C for up to a year maintains most growth factor levels, with EGF and IGF even higher than in fresh samples.

research A Comprehensive Review on Platelet-Rich Plasma Activation: A Key Player in Accelerating Skin Wound Healing

2 citations , November 2023 in “Curēus”

This review explores platelet-rich plasma's role in wound healing and discusses its potential as a broadly applicable therapeutic option, but it reports no new clinical results.

research Immunomorphological Features of Women's Skin with Androgenetic Alopecia in the Treatment of Plasma Enriched with Platelets in Combination with Topical Minoxidil 2% Lotion

December 2021 in “Journal of V. N. Karazin Kharkiv National University: Series Medicine”

In this study, treatment with platelet-rich plasma combined with 2% minoxidil was associated with normalization of immunohistochemical markers in patients with stage I-II androgenetic alopecia, suggesting potential for long-term therapeutic effects.

research Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

848 citations , October 2020 in “International Journal of Molecular Sciences”

This review discusses the potential of platelet-rich plasma applications in regenerative medicine and explores recent progress and challenges in translating non-clinical PRP findings into human treatments, but reports no new clinical results.