A Comprehensive Review on Platelet-Rich Plasma Activation: A Key Player in Accelerating Skin Wound Healing

November 2023 in “ Curēus ”

Hardik Patel, Aditya Pundkar, Sandeep Shrivastava, Rohan Chandanwale, Ankit M Jaiswal

platelet-rich plasma PRP growth factors bioactive molecules cell proliferation angiogenesis tissue repair chronic wounds acute wounds cosmetic procedures calcium chloride thrombin localized adverse reactions infection risks standardized preparation activation techniques regenerative medicine

Studysummary This review explores platelet-rich plasma's role in wound healing and discusses its potential as a broadly applicable therapeutic option, but it reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The review article discusses the potential of platelet-rich plasma (PRP) in enhancing skin wound healing by leveraging its rich concentration of growth factors and bioactive molecules to promote cell proliferation, angiogenesis, and tissue repair. It highlights PRP's clinical applications in chronic and acute wounds, as well as cosmetic procedures, showing improved wound closure rates and reduced infection. Various activation methods, such as calcium chloride and thrombin, are examined for their impact on growth factor release. Safety concerns, including localized adverse reactions and infection risks, are noted, emphasizing the need for standardized preparation and activation techniques. The review underscores PRP's transformative potential in wound healing and regenerative medicine, aiming to improve patient outcomes and reduce healthcare costs.

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