A Comprehensive Review on Platelet-Rich Plasma Activation: A Key Player in Accelerating Skin Wound Healing

The review article discusses the potential of platelet-rich plasma (PRP) in enhancing skin wound healing by leveraging its rich concentration of growth factors and bioactive molecules to promote cell proliferation, angiogenesis, and tissue repair. It highlights PRP's clinical applications in chronic and acute wounds, as well as cosmetic procedures, showing improved wound closure rates and reduced infection. Various activation methods, such as calcium chloride and thrombin, are examined for their impact on growth factor release. Safety concerns, including localized adverse reactions and infection risks, are noted, emphasizing the need for standardized preparation and activation techniques. The review underscores PRP's transformative potential in wound healing and regenerative medicine, aiming to improve patient outcomes and reduce healthcare costs.