Platelet Therapeutics to Improve Tissue Regeneration and Wound Healing: Physiological Background and Methods of Preparation

The document reviews the multifaceted role of platelets in hemostasis, tissue repair, and immune response, and the use of platelet-rich concentrates for therapeutic purposes in clinical settings. It explains that platelets release mediators that coordinate tissue repair and that local application of platelet-rich concentrates and fibrin can enhance wound healing in medicine and dentistry. The review details the preparation methods for platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), which involve centrifugation of blood, with or without anticoagulants, to concentrate platelets. The document acknowledges the potential of PRP and PRF in treating various conditions, including alopecia and skin rejuvenation, but also notes the current limitations due to small study sizes and potential bias, highlighting the need for more standardized and well-designed studies. The authors, E.E.J. and M.H., with contributions from A.B. and P.J., report no external funding or conflicts of interest.